Risk of Severe COVID-19 Infection in Patients With Inflammatory Rheumatic Diseases.

Autor:	Bachiller-Corral J; J. Bachiller-Corral, MD, Assistant Head, A. Boteanu, MD, Assistant Head, M. Vazquez-Diaz, MD, Department Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, and Irycis (Instituto Ramón y Cajal de investigación sanitaria), Madrid; fbachiller@salud.madrid.org., Boteanu A; J. Bachiller-Corral, MD, Assistant Head, A. Boteanu, MD, Assistant Head, M. Vazquez-Diaz, MD, Department Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, and Irycis (Instituto Ramón y Cajal de investigación sanitaria), Madrid., Garcia-Villanueva MJ; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., de la Puente C; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Revenga M; M. Revenga, MD, PhD, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid, and Facultad de Medicina. Universidad de Alcalá, Alcalá de Henares, Spain., Diaz-Miguel MC; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Rodriguez-Garcia A; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Morell-Hita JL; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Valero M; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Larena C; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Blazquez-Cañamero M; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Guillen-Astete CA; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Garrote S; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Sobrino C; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Medina-Quiñones C; M.J. Garcia-Villanueva, MD, Assistant Head, C. de la Puente, MD, Assistant Head, M.C. Diaz-Miguel, MD, Assistant Head, A. Rodriguez-Garcia, MD, Assistant Head, J.L. Morell-Hita, MD, Assistant Head, M. Valero, MD, Assistant Head, C. Larena, MD, Assistant Head, M. Blazquez-Cañamero, MD, Assistant Head, C.A. Guillen-Astete, MD, PhD, Assistant Head, S. Garrote, MD, Assistant Head, C. Sobrino, MD, Assistant Head, C. Medina-Quiñones, MD, Assistant Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, Madrid., Vazquez-Diaz M; J. Bachiller-Corral, MD, Assistant Head, A. Boteanu, MD, Assistant Head, M. Vazquez-Diaz, MD, Department Head, Department of Rheumatology, Hospital Universitario Ramón y Cajal, and Irycis (Instituto Ramón y Cajal de investigación sanitaria), Madrid.
Jazyk:	angličtina
Zdroj:	The Journal of rheumatology [J Rheumatol] 2021 Jul; Vol. 48 (7), pp. 1098-1102. Date of Electronic Publication: 2021 Mar 15.
DOI:	10.3899/jrheum.200755
Abstrakt:	Objective: To describe the cohort of patients with inflammatory rheumatic diseases (IRD) hospitalized due to SARS-CoV-2 infection in the Ramón y Cajal Hospital, and to determine the increased risk of severe coronavirus disease 2019 (COVID-19) in patients with no IRD. Methods: This is a retrospective single-center observational study of patients with IRD actively monitored in the Department of Rheumatology who were hospitalized due to COVID-19. Results: Forty-one (1.8%) out of 2315 patients admitted due to severe SARS-CoV-2 pneumonia suffered from an IRD. The admission OR for patients with IRD was 1.91 against the general population, and it was considerably higher in patients with Sjögren syndrome, vasculitis, and systemic lupus erythematosus. Twenty-seven patients were receiving treatment for IRD with corticosteroids, 23 with conventional DMARDs, 12 with biologics (7 rituximab [RTX], 4 anti-tumor necrosis factor [anti-TNF], and 1 abatacept), and 1 with Janus kinase inhibitors. Ten deaths were registered among patients with IRD. A higher hospitalization rate and a higher number of deaths were observed in patients treated with RTX (OR 12.9) but not in patients treated with anti-TNF (OR 0.9). Conclusion: Patients with IRD, especially autoimmune diseases and patients treated with RTX, may be at higher risk of severe pneumonia due to SARS-CoV-2 compared to the general population. More studies are needed to analyze this association further in order to help manage these patients during the pandemic. (Copyright © 2021 by the Journal of Rheumatology.)
Databáze:	MEDLINE
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