Polyvinyl alcohol based-drug delivery systems for cancer treatment.

Autor: Rivera-Hernández G; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnologia-FEMSA, Ave. Eugenio Garza Sada 2501, Monterrey, Mexico; Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Argentina., Antunes-Ricardo M; Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnologia-FEMSA, Ave. Eugenio Garza Sada 2501, Monterrey, Mexico., Martínez-Morales P; CONACYT- Centro de Investigación Biomédica de Oriente-IMSS, Km 4.5 Carretera Federal Atlixco-Metepec, 74360 Metepec, Puebla, Mexico., Sánchez ML; Laboratorio de Materiales Biotecnológicos (LaMaBio), Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, IMBICE-CONICET, Bernal, Argentina. Electronic address: mirna.sanchez@unq.edu.ar.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2021 May 01; Vol. 600, pp. 120478. Date of Electronic Publication: 2021 Mar 12.
DOI: 10.1016/j.ijpharm.2021.120478
Abstrakt: Polyvinyl alcohol (PVA) is a biodegradable semicrystalline synthetic polymer that has been used for biomedical applications for several years. In the pharmaceutical area, PVA has been widely used to prepare solid dispersions to improve the solubility of drugs. Furthermore, it has been demonstrated that PVA is highly biocompatible and non-toxic in in-vitro and in-vivo studies. Several reports provided in this review suggest a promising strategy for cancer treatment. Thus far, the current therapy includes a combination of surgery, chemotherapy, and radiotherapy, the effectivity can be limited due to the heterogeneous manifestations of the disease, dose-related toxicity, and side effects. A promising strategy is the implementation of a targeted therapy using hydrogels, microparticles, or nanoparticles (NPs), capable of encapsulating, protecting, transporting, and targeted administration of a therapeutic agent. Considering the relevance of the PVA in conjunction with their copolymers, it has become a promising biodegradable material to build novel functional composites used in the fabrication of hydrogels, microparticles, nanoparticles, and nanocomposites for drug delivery systems in cancer treatment.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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