The Autoantigen Repertoire and the Microbial RNP World.

Autor: Williams SG; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, USA; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute (NCI), NIH, Frederick, MD 21702, USA. Electronic address: sandra.williams@nih.gov., Wolin SL; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute (NCI), NIH, Frederick, MD 21702, USA. Electronic address: sandra.wolin@nih.gov.
Jazyk: angličtina
Zdroj: Trends in molecular medicine [Trends Mol Med] 2021 May; Vol. 27 (5), pp. 422-435. Date of Electronic Publication: 2021 Mar 12.
DOI: 10.1016/j.molmed.2021.02.003
Abstrakt: Although autoimmunity and autoimmune disease (AID) are relatively common, the repertoire of autoantigens is paradoxically very limited. Highly enriched in this autoantigen repertoire are nucleic acids and their binding proteins, which together form large macromolecular structures. Most of these complexes are of ancient evolutionary origin, with homologs throughout multiple kingdoms of life. Why and if these nucleic acid-protein particles drive the development of autoimmunity remains unresolved. Recent advances in our understanding of the microbiome may provide clues about the origins of autoimmunity - and the particular puzzle of why the autoantigen repertoire is so particularly enriched in ribonucleoprotein particles (RNPs). We discuss the possibility that autoimmunity to some RNPs may arise from molecular mimicry to microbial orthologs.
Competing Interests: Declaration of Interests There are no interests to declare.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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