[Experience of olokizumab use in COVID-19 patients].

Autor:	Antonov VN; South Ural State Medical University.; Regional Clinical Hospital №3., Ignatova GL; South Ural State Medical University.; Regional Clinical Hospital №3., Pribytkova OV; South Ural State Medical University.; Regional Clinical Hospital №3., Sleptsova SS; Ammosov North-Eastern Federal University., Strebkova EA; Seredavin Samara Regional Clinical Hospital.; Samara State Medical University, Samara., Khudyakova EA; Luke of Crimea Stary Oskol District Hospital, Belgorod Region., Simakov AI; Pacific State Medical University.; Territorial Clinical Hospital №2., Rabets SY; Norilsk Inter-District Hospital №1., Tikhonova EP; Voyno-Yasenetsky Krasnoyarsk State Medical University.; Karpovich Krasnoyarsk Inter-District Clinical Emergency Hospital., Kurmaeva DY; Penza Regional Clinical Tertiary Care Centre., Petrushin MA; Tver Region Regional Clinical Hospital., Mashkov AS; Voronovskoye Moscow Clinical Center for Infectious Diseases., Gayazova EV; Nizhny Novgorod Region City Clinical Hospital №3 (Nizhny Novgorod Geriatric Center)., Yasheva IV; Temporary Infectious Diseases Hospital for Coronavirus Disease based at the Cherkess City Clinical Hospital., Andreev MA; Republican Tuberculosis Dispensary., Khinovker VV; Siberian Clinical Research Center., Karpunin AY; Regional Clinical Hospital., Berezhanskiy BV; R-Pharm JSC.
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2020 Dec 15; Vol. 92 (12), pp. 148-154. Date of Electronic Publication: 2020 Dec 15.
DOI:	10.26442/00403660.2020.12.200522
Abstrakt:	Most subjects with the COVID-19 experience mild to moderate symptoms, but approximately 10% of cases suffer from severe course of disease. IL-6 inhibitors are actively used to neutralize and prevent the cytokine storm. Olokizumab is a humanized monoclonal antibody belonging to the G4/Kappa immunoglobulin isotype that selectively binds to human IL-6 and effectively neutralizes it. Aim: To evaluate the efficacy and safety of Artlegia (olokizumab) for the treatment of subjects with a disease caused by the SARS-COV-2 virus in a real-world clinical setting. Materials and Methods: The analysis included data of 610 subjects aged 55.0812.68 years who received olokizumab at a single dose of 160 mg/mL 0.4 mL subcutaneously as a preemptive anti-inflammatory therapy. The comparison group included 511 subjects aged 55.2311.23 years who received standard therapy without IL-6 inhibitors. Control Endpoints: 1. Positive clinical changes on Day 7. 2. Changes in the CRP levels on Days 1, 2, and 7. 3. Duration of oxygen therapy. 4. Number of days in hospital. 5. Number of adverse events. 6. Disease outcome. Results: If a cytokine storm occurs, immune regulatory events will trigger the development of either a protective immune response or an exacerbated inflammatory response. The use of preemptive anti-inflammatory therapy has both a short-term and, most importantly, a long-term effect on the T and B parts of the immune process. These aspects definitely require further research and observation. Conclusion: The use of olokizumab to treat the new COVID-19 coronavirus disease has demonstrated a positive effect on clinical and laboratory parameters. Primarily, it affects the severity of clinical parameters by improving the general condition already on the first day of observation, and decreasing body temperature to normal values. The changes in the C-reactive protein levels show a significant effect of the IL-6 inhibitor on the systemic inflammatory response.
Databáze:	MEDLINE
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