A rare cause of acute liver failure due to haemophagocytic lymphohistiocytosis secondary to diffuse large B-cell lymphoma.
| Autor: | Coppola A; Department of Surgery and Cancer, Imperial College London Faculty of Medicine, London SW7 2BU, UK., Chey C; Department of Gastroenterology, Surrey and Sussex Healthcare NHS Trust, Surrey RH1 5RH, UK., O'Donovan E; Department of Haematology, Surrey and Sussex Healthcare NHS Trust, Surrey RH1 5RH, UK., Rahman M; Department of Gastroenterology, Surrey and Sussex Healthcare NHS Trust, Surrey RH1 5RH, UK. |
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| Jazyk: | angličtina |
| Zdroj: | JRSM open [JRSM Open] 2021 Mar 02; Vol. 12 (3), pp. 2054270420983623. Date of Electronic Publication: 2021 Mar 02 (Print Publication: 2021). |
| DOI: | 10.1177/2054270420983623 |
| Abstrakt: | Acute liver failure is a life-threatening condition commonly caused by drug-induced hepatotoxicity or viral hepatitides. However, there are a number of rarer causes such as haemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis is a syndrome of uncontrolled immune cell activation, triggered by infection or malignancy, which carries a high mortality. Whilst mild to moderate liver injury is commonly seen with haemophagocytic lymphohistiocytosis, acute liver failure has rarely been reported in adults. We present a case of a 74-year-old man with acute liver failure secondary to haemophagocytic lymphohistiocytosis triggered by undiagnosed large B-cell lymphoma. Initially treated for biliary sepsis, there was a delay in the diagnosis of haemophagocytic lymphohistiocytosis and despite initiating chemotherapy, he died soon after. This case highlights the importance of considering haemophagocytic lymphohistiocytosis as a rare cause of acute liver failure, as given the life-threatening potential of haemophagocytic lymphohistiocytosis, a prompt diagnosis may allow early initiation of chemotherapy for any chance of survival. (© The Author(s) 2021.) |
| Databáze: | MEDLINE |
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