Big Five Personality and CTRA gene expression: Lack of association in a midlife sample of US adults (MIDUS-Refresher).

Autor: Hobbs KA; University of Minnesota, Twin Cities Department of Psychology 75 E River Rd Minneapolis, MN 55455, United states., Mann FD; University of Minnesota, Twin Cities Department of Psychology 75 E River Rd Minneapolis, MN 55455, United states., Cole SW; University of California, Los Angeles Department of Psychiatry & Biobehavioral Sciences and Medicine 11-934 Factor Building Los Angeles, CA 90095, United States., Krueger RF; University of Minnesota, Twin Cities Department of Psychology 75 E River Rd Minneapolis, MN 55455, United states.
Jazyk: angličtina
Zdroj: Personality and individual differences [Pers Individ Dif] 2021 Feb 01; Vol. 169. Date of Electronic Publication: 2020 Feb 28.
DOI: 10.1016/j.paid.2020.109908
Abstrakt: A previous study found that Extraversion and Conscientiousness were associated with increased and decreased expression of a pre-specified set of pro-inflammatory indicator genes. The present study aimed to replicate these findings in a sample of adults from the Refresher Cohort of the Study of Midlife in the United States (MIDUS). Analysis of gene expression composite scores and generalized linear models that took into account the heterogeneity and non-independence of RNA expression across different genes found no significant associations between the pro-inflammatory indicator gene set and the Big Five domains of personality. In addition, there was no significant association between a pre-specified antiviral indicator gene set and the Big Five domains. These findings suggest that relations between Big Five personality and expression of these two immune response indicator gene sets do not consistently appear across samples and may be context-dependent in ways that remain to be elucidated.
Databáze: MEDLINE
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