Application of Chemical Exchange Saturation Transfer (CEST) in neuroimaging.

Autor: Mamoune KE; Physiologie de la Reproduction et des Comportements, UMR 085 INRAE, CNRS 7247, Université de Tours, IFCE, Centre INRAE Val de Loire, 37380 Nouzilly, France; Siemens Healthcare SAS, Saint Denis, France; SFR FED 4226, Université de Tours, 2 Bd Tonnellé, 37032 Tours, France., Barantin L; iBrain, UMR 1253 INSERM, Université de Tours, 10 Bd Tonnellé, 37032 Tours, France; SFR FED 4226, Université de Tours, 2 Bd Tonnellé, 37032 Tours, France., Adriaensen H; Physiologie de la Reproduction et des Comportements, UMR 085 INRAE, CNRS 7247, Université de Tours, IFCE, Centre INRAE Val de Loire, 37380 Nouzilly, France; CIRE UMR 085 INRAE, CNRS 7247, Université de Tours, IFCE, Centre INRAE Val de Loire, 37380 Nouzilly, France; SFR FED 4226, Université de Tours, 2 Bd Tonnellé, 37032 Tours, France., Tillet Y; Physiologie de la Reproduction et des Comportements, UMR 085 INRAE, CNRS 7247, Université de Tours, IFCE, Centre INRAE Val de Loire, 37380 Nouzilly, France; SFR FED 4226, Université de Tours, 2 Bd Tonnellé, 37032 Tours, France. Electronic address: yves.tillet@inrae.fr.
Jazyk: angličtina
Zdroj: Journal of chemical neuroanatomy [J Chem Neuroanat] 2021 Jul; Vol. 114, pp. 101944. Date of Electronic Publication: 2021 Mar 11.
DOI: 10.1016/j.jchemneu.2021.101944
Abstrakt: Since the early eighties MRI has become the most powerful technic for in-vivo imaging particularly in the field of brain research. This non-invasive method allows acute anatomical observations of the living brain similar to post-mortem dissected tissues. However, one of the main limitation of MRI is that it does not make possible the neurochemical identification of the tissues conversely to positron emission tomography scanner which can provide a specific molecular characterization of tissue, in spite of poor anatomical definition. To gain neurochemical information using MRI, new categories of contrast agents were developed from the beginning of the 2000's, particularly using the chemical-exchange saturation transfer (CEST) method. This method induces a significant change in the magnitude of the water proton signal and allows the detection of specific molecules within the tissues like sugars, amino acids, transmitters, and nucleosides. This short review presents several CEST contrast agents and their recent developments for in vivo detection of metabolites and neurotransmitters in the brain for research and clinical purposes.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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