Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats.

Autor:	Helke KL; Department of Comparative Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Meyerholz DK; Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA., Beck AP; Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA., Burrough ER; Veterinary Diagnostic and Production Animal Medicine Department, Iowa State University, Ames, Iowa, USA., Derscheid RJ; Veterinary Diagnostic and Production Animal Medicine Department, Iowa State University, Ames, Iowa, USA., Löhr C; Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon, USA., McInnes EF; Toxicologic Pathology, Toxicology Section, Human Safety at Syngenta, in Jealott's Hill, Bracknell, United Kingdom., Scudamore CL; ExePathology, Pathologist at ExePathology, Exmouth, Devon, United Kingdom., Brayton CF; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jazyk:	angličtina
Zdroj:	ILAR journal [ILAR J] 2021 Dec 31; Vol. 62 (1-2), pp. 133-168.
DOI:	10.1093/ilar/ilab005
Abstrakt:	Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but also awareness of spontaneous conditions and background lesions in the model that can influence or even confound the study results. Species, breed/stock, sex, age, anatomy, physiology, diseases (noninfectious and infectious), and neoplastic processes are model features that can impact the results as well as study interpretation. Here, we review these features in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats. (© The Author(s) 2021. Published by Oxford University Press on behalf of the National Academies of Sciences, Engineering, and Medicine. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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