Deep-sea microbes as tools to refine the rules of innate immune pattern recognition.

Autor:	Gauthier AE; Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.; Program in Virology, Harvard Medical School, Boston, MA 02115, USA.; Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA., Chandler CE; Department of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA., Poli V; Harvard Medical School, and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA 02115, USA., Gardner FM; Department of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA., Tekiau A; Ministry of Fisheries, Republic of Kiribati, Tarawa, Kiribati., Smith R; Department of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA., Bonham KS; Department of Biological Sciences, Wellesley College, 106 Central St., Wellesley, MA 02481, USA., Cordes EE; Department of Biology, Temple University, 1900 N. 12th St., Philadelphia, PA 19122, USA., Shank TM; Biology Department, MS33, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA., Zanoni I; Harvard Medical School, and Boston Children's Hospital, Division of Immunology, Division of Gastroenterology, Boston, MA 02115, USA., Goodlett DR; Department of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.; International Centre for Cancer Vaccine Science, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, Poland., Biller SJ; Department of Biological Sciences, Wellesley College, 106 Central St., Wellesley, MA 02481, USA., Ernst RK; Department of Microbial Pathogenesis, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA., Rotjan RD; Department of Biology, Boston University, 5 Cummington Mall, Boston, MA 02215, USA. jonathan.kagan@childrens.harvard.edu rrotjan@bu.edu., Kagan JC; Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. jonathan.kagan@childrens.harvard.edu rrotjan@bu.edu.
Jazyk:	angličtina
Zdroj:	Science immunology [Sci Immunol] 2021 Mar 12; Vol. 6 (57).
DOI:	10.1126/sciimmunol.abe0531
Abstrakt:	The assumption of near-universal bacterial detection by pattern recognition receptors is a foundation of immunology. The limits of this pattern recognition concept, however, remain undefined. As a test of this hypothesis, we determined whether mammalian cells can recognize bacteria that they have never had the natural opportunity to encounter. These bacteria were cultivated from the deep Pacific Ocean, where the genus Moritella was identified as a common constituent of the culturable microbiota. Most deep-sea bacteria contained cell wall lipopolysaccharide (LPS) structures that were expected to be immunostimulatory, and some deep-sea bacteria activated inflammatory responses from mammalian LPS receptors. However, LPS receptors were unable to detect 80% of deep-sea bacteria examined, with LPS acyl chain length being identified as a potential determinant of immunosilence. The inability of immune receptors to detect most bacteria from a different ecosystem suggests that pattern recognition strategies may be defined locally, not globally. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
Databáze:	MEDLINE
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