Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents.

Autor: Wunram HL; Department of Child and Adolescent Psychiatry Psychosomatic and Psychotherapy, University Hospital of Cologne, Cologne, Germany. heidrun-lioba.wunram@uk-koeln.de., Hamacher S; Department of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Cologne, Germany., Oberste M; Department of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Cologne, Germany.; Department for Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, Germany., Neufang S; Department of Psychiatry and Psychotherapy, Medical Faculty Heinrich-Heine University, Düsseldorf, Germany., Belke L; Children's Hospital Amsterdam Street, Cologne, Germany., Jänicke F; Clinic for Psychiatry Marienborn, Düren, Germany., Graf C; Institute of Movement and Neuroscience, German Sport University Cologne, Cologne, Germany., Schönau E; Children's Hospital, University Hospital of Cologne and UniReha®, University Hospital of Cologne, Cologne, Germany., Bender S; Department of Child and Adolescent Psychiatry Psychosomatic and Psychotherapy, University Hospital of Cologne, Cologne, Germany., Fricke O; Department of Child and Adolescent Psychiatry, Psychotherapy and Child Neurology, Gemeinschaftskrankenhaus Herdecke and Chairs of Child and Adolescent Psychiatry, Witten/Herdecke University, Witten, Germany.
Jazyk: angličtina
Zdroj: European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2022 Jul; Vol. 31 (7), pp. 1-14. Date of Electronic Publication: 2021 Mar 12.
DOI: 10.1007/s00787-021-01742-5
Abstrakt: Recent meta-analyses reveal a moderate effect of physical activity (PA) in the treatment of adolescent depression. However, not only the underlying neurobiological mechanisms, also the influences of placebo-related motivational factors (beliefs and expectancies in sporting, enjoyment and prior sports experiences), are still unclear. Based on the data of our prior study "Mood Vibes", we hypothesized that placebo-inherent factors like positive prior sports experiences and motivational factors, (positive beliefs, expectancies, and enjoyment related to PA), would increase the effects of an add-on exercise-therapy in juvenile depression. From 64 included depressed adolescents, 41 underwent an intensive add-on PA-therapy. Motivational factors were assessed using sport-specific scales. The changes in depression scores under treatment were rated by self-rating scale (German "Childhood Depression Inventory", (DIKJ)). A mixed model for repeated measures (MMRM) was used to analyze the effects of the different motivational variates on DIKJ. While prior sports experiences had no impact, motivational factors showed a significant effect on PA-induced changes in DIKJ scores (p = 0.002). The demotivated participants improved less, whereas it was sufficient to be neutral towards sporting to benefit significantly more. Motivational placebo-related factors (beliefs, expectancies and enjoyment regarding PA) affected the outcomes of an exercise treatment in depressed adolescents. Yet, a neutral mindset was sufficient to profit more from PA. Prior sporting in the sense of positive conditioning and as a protective factor did not play a role. Knowledge about these influences could in a second step help to develop tailored therapies.
(© 2021. The Author(s).)
Databáze: MEDLINE
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