Acute stress increases monocyte levels and modulates receptor expression in healthy females.

Autor: van de Wouw M; APC Microbiome Ireland, University College Cork, Cork, Ireland., Sichetti M; Unit of Biochemical Sciences and Health, Department of Pharmaceutical Sciences, University of Perugia, Italy., Long-Smith CM; APC Microbiome Ireland, University College Cork, Cork, Ireland., Ritz NL; APC Microbiome Ireland, University College Cork, Cork, Ireland., Moloney GM; APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland., Cusack AM; APC Microbiome Ireland, University College Cork, Cork, Ireland., Berding K; APC Microbiome Ireland, University College Cork, Cork, Ireland., Dinan TG; APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioral Science, University College Cork, Cork, Ireland., Cryan JF; APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland. Electronic address: j.cryan@ucc.ie.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2021 May; Vol. 94, pp. 463-468. Date of Electronic Publication: 2021 Mar 09.
DOI: 10.1016/j.bbi.2021.03.005
Abstrakt: There has been a growing recognition of the involvement of the immune system in stress-related disorders. Acute stress leads to the activation of neuroendocrine systems, which in turn orchestrate a large-scale redistribution of innate immune cells, such as monocytes. Even though acute stress/monocyte interactions have been well-characterized in mice, this is not the case for humans. As such, this study aimed to investigate whether acute stress modulates blood monocyte levels in a subtype-dependent manner and whether the receptor expression of stress-related receptors is affected in humans. Blood was collected from healthy female volunteers at baseline and 1 h after the socially evaluated cold pressor test, after which blood monocyte levels and receptor expression were assessed by flow cytometry. Our results reveal a stress-induced increase in blood monocyte levels, which was independent of monocyte subtypes. Furthermore, colony stimulating factor 1 receptor (CSF-1R) and CD29 receptor expression was increased, while CD62L showed a trend towards increased expression. These results provide novel insights into how acute stress affects the innate immune system.
(Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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