Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation Therapy.

Autor: Cardoso FDS; Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Av. Cândido Xavier de Almeida e Souza, 200, Mogi das Cruzes, São Paulo, SP, CEP 08780-911, Brazil., de Souza Oliveira Tavares C; Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Av. Cândido Xavier de Almeida e Souza, 200, Mogi das Cruzes, São Paulo, SP, CEP 08780-911, Brazil., Araujo BHS; Laboratório Nacional de Biociências (LNBio), Centro Nacional de Pesquisa Em Energia E Materiais (CNPEM), Campinas, SP, Brazil., Mansur F; Center for Experimental Research, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Lopes-Martins RÁB; Laboratory of Biophotonics and Experimental Therapeutics in Health and Esthetics, Universidade Brasil - UB, São Paulo, SP, Brazil., Gomes da Silva S; Núcleo de Pesquisas Tecnológicas, Universidade de Mogi das Cruzes, Av. Cândido Xavier de Almeida e Souza, 200, Mogi das Cruzes, São Paulo, SP, CEP 08780-911, Brazil. sergio.silva@fcv.org.br.; Centro Universitário UNIFAMINAS (UNIFAMINAS), Muriaé, MG, Brazil. sergio.silva@fcv.org.br.; Hospital Do Câncer de Muriaé, Fundação Cristiano Varella (FCV), Muriaé, MG, Brazil. sergio.silva@fcv.org.br.
Jazyk: angličtina
Zdroj: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2022 Aug; Vol. 42 (6), pp. 1875-1886. Date of Electronic Publication: 2021 Mar 11.
DOI: 10.1007/s10571-021-01069-4
Abstrakt: Recent evidences have shown the therapeutic potential of transcranial photobiomodulation on traumatic brain injury and Alzheimer's disease. Despite the promising benefits in the brain, little is known about the laser's effects in the absence of pathological conditions. We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their exploratory activity and habituation in open field, anxiety in elevated plus maze, spatial memory in Barnes maze, and aversive memory in a step-down inhibitory avoidance task. Additionally, the levels of a panel of inflammatory cytokines and chemokines were quantified in two different brain regions: the cerebral cortex and the hippocampus. Young and aged rats submitted to transcranial laser exhibited better cognitive performance in Barnes maze than did control rats. Transcranial laser therapy decreased cortical levels of GM-CSF, IL-10, MCP-1, LIX, and TNFα in young rats and IL-5 in aged rats. High levels of IL-6, IL-10, and TNF-alpha were found in the cerebral cortex of aged rats submitted to transcranial laser. In the hippocampus, a decrease in IP-10 and fractalkine levels was observed in the aged rats from the laser group when compared to the aged rats from the control group. Our data indicate that transcranial photobiomodulation improves spatial learning and memory and alters the neuroinflammatory profile of young and aged rats' brains.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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