| Autor: |
Ngo NTN; Faculty of Chemistry, University of Science, VNU-HCM, Ho Chi Minh City, Vietnam.; Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam., Lai NTDDT; Faculty of Chemistry, University of Science, VNU-HCM, Ho Chi Minh City, Vietnam.; Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam., Le HC; Faculty of Chemistry, University of Science, VNU-HCM, Ho Chi Minh City, Vietnam.; Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen LT; Faculty of Chemistry, University of Science, VNU-HCM, Ho Chi Minh City, Vietnam.; Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam., Trinh BTD; Faculty of Chemistry, University of Science, VNU-HCM, Ho Chi Minh City, Vietnam.; Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen HD; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Pham PD; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Dang SV; Institute of Tropical Biology, VAST, Ho Chi Minh City, Vietnam., Nguyen LD; Faculty of Chemistry, University of Science, VNU-HCM, Ho Chi Minh City, Vietnam.; Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam. |
| Abstrakt: |
Two new rocaglamides, 8b- O -5-oxohexylrocaglaol ( 1 ) and elaeagnin ( 2 ), together with twelve known compounds, were isolated from the bark of Aglaia elaeagnoidea and the whole tree of A. odorata . Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Cytotoxic activity against HepG2 human liver cancer cells of the isolated compounds was evaluated in vitro using the SRB assay. Three rocaglamide derivatives, dehydroaglaiastatin ( 13 ), 8b- O -5-oxohexylrocaglaol ( 1 ) and rocaglaol ( 5 ), exhibited significant effects with IC 50 values of 0.69, 4.77 and 7.37 µM, respectively. |
