High-fat diet and fructose drink introduced after weaning rats, induces a better human obesity model than very high-fat diet.

Autor: Lima TDR; Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.; Department of Health Sciences and Nutrition, Academic Center of Varzea Grande, Várzea Grande, Brazil., Voltarelli FA; Department of Basic Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Brazil., Freire LS; Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil., da Silva FA; Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil., de Almeida PC; Department of Basic Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Brazil., Ávila ETP; Department of Basic Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Brazil., de França SA; Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil., Pereira MP; Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil., Damazo AS; Department of Basic Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Brazil., Navalta JW; Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, Nevada., Fett CA; Department of Basic Health Sciences, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Brazil., Kawashita NH; Department of Chemistry, Federal University of Mato Grosso, Cuiabá, Brazil.
Jazyk: angličtina
Zdroj: Journal of food biochemistry [J Food Biochem] 2021 Apr; Vol. 45 (4), pp. e13671. Date of Electronic Publication: 2021 Mar 10.
DOI: 10.1111/jfbc.13671
Abstrakt: In the present study, we associated a high-fat diet (HF group: 45% kcal from lipids) or very high-fat (VHF group: 60% kcal from lipids) diet with a fructose drink (10% fructose) for hydration. Normal rat chow that received the control diet (content 16.3% kcal from lipid-AIN93G) and water. The treatments were introduced soon after weaning and were administered for 70 days. We aimed to compare HF and VHF groups and find which acts as a better model mimicking human obesity. Body mass gain, final body weight, adipocyte area in inguinal depots, visceral and subcutaneous adipose depots, serum triacylglycerol, and VLDL-c were all higher in the HF group, followed by the VHF group, compared to the C group. Only the HF group showed hyperinsulinemia and hyperleptinemia and higher total caloric intake, Lee index, HOMA2-IR, and total cholesterol. Serum TNF-α and IL-6 levels were lower in the HF and VHF groups than in the C group at the end for 70 days. In Summary, the HF (45%) diet administered with fructose induced a higher similarity of metabolic and hormonal alterations associated with human obesity. PRACTICAL APPLICATIONS: High intake of lipids with sugary drinks has been associated with obesity and its comorbidities. Although a diet with 45% or 60% of lipids is considered hyperlipidic, they are different in their effects on eating behavior and also probably from a metabolic point of view. Common sense is that the reduction in intake of lipids is favorable to health. Our study shows that this is not wholly true, and this information contributes to the guidelines for the treatment of obesity. In addition, the scientific literature on the subject has shown the most diverse results and also the use of experimental models with few similarities with human obesity. Our findings can contribute as a good model of obesity initiated during childhood to investigate possible using nutritional strategies, or the adoption of ergogenic nutritional resources in future studies, for example.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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