A randomized, controlled proof-of-concept trial evaluating durable effects of memory flexibility training (MemFlex) on autobiographical memory distortions and on relapse of recurrent major depressive disorder over 12 months.

Autor: Hitchcock C; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK. Electronic address: caitlin.hitchcock@mrc-cbu.cam.ac.uk., Smith AJ; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Elliott R; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., O'Leary C; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Gormley S; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Parker J; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Patel SD; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Esteves CV; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Rodrigues E; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Hammond E; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK; University of Exeter, UK., Watson P; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK., Werner-Seidler A; The Black Dog Institute, UNSW, Sydney, Australia., Dalgleish T; Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, UK.
Jazyk: angličtina
Zdroj: Behaviour research and therapy [Behav Res Ther] 2021 May; Vol. 140, pp. 103835. Date of Electronic Publication: 2021 Mar 03.
DOI: 10.1016/j.brat.2021.103835
Abstrakt: Low-intensity psychological interventions that target cognitive risk factors for depressive relapse may improve access to relapse prevention programs and thereby reduce subsequent risk. This study provides the first evaluation of an autobiographical memory-based intervention for relapse prevention, to establish whether memory-training programs that are efficacious for acute depression may also aid those currently in remission. We also provide the longest follow-up to-date of the effects of autobiographical memory training on autobiographical memory processes themselves. This pre-registered randomized-controlled proof-of-concept trial (N = 74) compared an autobiographical Memory Flexibility (MemFlex) intervention to Psychoeducation about cognitive-behavioral mechanisms which maintain depression. Both interventions were primarily self-guided, and delivered via paper workbooks completed over four weeks. The key cognitive outcome was ability to retrieve and alternate between specific and general autobiographical memories. Co-primary clinical outcomes were time until depressive relapse and depression-free days in the twelve-months following intervention. Results indicated a small-moderate effect size (d = 0.35) in favor of MemFlex for the cognitive outcome. A small Hazard Ratio (1.08) was observed for time until depressive relapse, along with a negligible effect size for depression-free days (d = 0.11). Although MemFlex produced long-term improvement in memory retrieval skills, there was little support for MemFlex as a relapse prevention program for depression.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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