Age-related Decline in Renal Function is Attenuated in Master Athletes.

Autor:	Rosa TDS; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Corrêa HL; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Barbosa LP; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Santos PAD; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Leite PLA; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Aguiar SS; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Deus LA; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Maciel LA; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Neves RVP; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil., Simoes HG; Graduate Program on Physical Education and Health, Catholic University of Brasilia, Taguatinga, Brazil.
Jazyk:	angličtina
Zdroj:	International journal of sports medicine [Int J Sports Med] 2021 Sep; Vol. 42 (10), pp. 889-895. Date of Electronic Publication: 2021 Mar 08.
DOI:	10.1055/a-1332-1594
Abstrakt:	This study analyzed the kidney function and biomarkers of health in lifelong-trained sprinters and endurance runners, and compared them to untrained aged-matched and young controls. Sixty-two men (21-66 yr.) were recruited and allocated as master athletes from sprints (n=25), master athletes from endurance events (n=8), untrained middle-aged (n=14) and young controls (n=15). Participants underwent anamnesis, anthropometric measures and blood sampling for biochemical analyses of klotho, FGF23 and estimated glomerular filtration rate. Master sprinters presented better kidney function in relation to endurance athletes and their untrained peers ( P <0.0001). A number of biochemical variables were observed that negatively (i. e., GDF-15, TGF-Beta, IL-18) or positively (i. e., klotho/FGF23 ratio and sestrin-2) correlated with eGFR. Sestrin-2 presented the strongest association with eGFR (r=0.5, P =0.03). Results also revealed that lifelong-trained individuals presented the highest probability of having better values for cystatin C and thus an estimated glomerular filtration rate that was 37-49% higher than untrained peers. Master sprinters presented better kidney function in relation to endurance athletes and middle-aged untrained peers. Sestrin-2 may play a role in exercise-induced kidney function protection. Competing Interests: The authors declare that they have no conflict of interest (Thieme. All rights reserved.)
Databáze:	MEDLINE
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