The anti-diabetic drug alogliptin induces vasorelaxation via activation of Kv channels and SERCA pumps.
Autor: | Jung HS; Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Seo MS; Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., An JR; Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Heo R; Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Kang M; Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Han ET; Institute of Medical Sciences, Department of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Park H; Department of Urology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Song G; Department of Urology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea., Son YK; Biological and Genetic Resources Assessment Division, National Institute of Biological Resources, Incheon, 22689, South Korea., Jung WK; Department of Biomedical Engineering, Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, 48513, South Korea., Choi IW; Department of Microbiology, College of Medicine, Inje University, Busan, 48516, South Korea., Na SH; Institute of Medical Sciences, Department of Obstetrics and Gynecology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea. Electronic address: lahun@kangwon.ac.kr., Park WS; Institute of Medical Sciences, Department of Physiology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea. Electronic address: parkws@kangwon.ac.kr. |
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Jazyk: | angličtina |
Zdroj: | European journal of pharmacology [Eur J Pharmacol] 2021 May 05; Vol. 898, pp. 173991. Date of Electronic Publication: 2021 Mar 05. |
DOI: | 10.1016/j.ejphar.2021.173991 |
Abstrakt: | In the present study, we investigated the vasorelaxant effects of alogliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor class, using phenylephrine (Phe)-induced pre-contracted aortic rings. Alogliptin induced vasorelaxation in a dose-dependent manner. Pre-treatment with the voltage-dependent K + (Kv) channel inhibitor 4-aminopyridine (4-AP) significantly decreased the vasorelaxant effect of alogliptin, whereas pre-treatment with the inwardly rectifying K + (Kir) channel inhibitor Ba 2+ , ATP-sensitive K + (K (Copyright © 2021 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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