Thermoresponsive Hydrogel-Loading Aluminum Chloride Phthalocyanine as a Drug Release Platform for Topical Administration in Photodynamic Therapy.

Autor: de Oliveira ÉL; Department of Chemistry, Research Nucleus of Photodynamic Therapy, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Ferreira SBS; Department of Pharmacy, Laboratory of Research and Development of Drug Delivery Systems, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., de Castro-Hoshino LV; Department of Physics, Photothermal Phenomenon Research Group, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Campanholi KDSS; Department of Chemistry, Research Nucleus of Photodynamic Therapy, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Calori IR; Department of Chemistry, Research Nucleus of Photodynamic Therapy, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil.; Department of Chemistry, Center of Nanotechnology and Tissue Engineering, Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-901, Brazil., de Morais FAP; Department of Chemistry, Research Nucleus of Photodynamic Therapy, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Kimura E; Department of Pharmacy, Clinical Research and Bioequivalence Center, State University of Maringá, Avenue Mandacaru 1590, Maringá, Paraná 87083-240, Brazil., da Silva Junior RC; Department of Chemistry, Research Nucleus of Photodynamic Therapy, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Bruschi ML; Department of Pharmacy, Laboratory of Research and Development of Drug Delivery Systems, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Sato F; Department of Physics, Photothermal Phenomenon Research Group, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Hioka N; Department of Chemistry, Research Nucleus of Photodynamic Therapy, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil., Caetano W; Department of Chemistry, Research Nucleus of Photodynamic Therapy, State University of Maringá, Avenue Colombo 5790, Maringá, Paraná 87020-900, Brazil.
Jazyk: angličtina
Zdroj: Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2021 Mar 16; Vol. 37 (10), pp. 3202-3213. Date of Electronic Publication: 2021 Mar 08.
DOI: 10.1021/acs.langmuir.1c00148
Abstrakt: Phthalocyanine aluminum chloride (Pc) is a clinically viable photosensitizer (PS) to treat skin lesions worsened by microbial infections. However, this molecule presents a high self-aggregation tendency in the biological fluid, which is an in vivo direct administration obstacle. This study proposed the use of bioadhesive and thermoresponsive hydrogels comprising triblock-type Pluronic F127 and Carbopol 934P (FCarb) as drug delivery platforms of Pc (FCarbPc)-targeting topical administration. Carbopol 934P was used to increase the F127 hydrogel adhesion on the skin. Rheological analyses showed that the Pc presented a low effect on the hydrogel matrix, changing the gelation temperature from 27.2 ± 0.1 to 28.5 ± 0.9 °C once the Pc concentration increases from zero to 1 mmol L -1 . The dermatological platform showed matrix erosion effects with the release of loaded Pc micelles. The permeation studies showed the excellent potential of the FCarb platform, which allowed the partition of the PS into deeper layers of the skin. The applicability of this dermatological platform in photodynamic therapy was evaluated by the generation of reactive species which was demonstrated by chemical photodynamic efficiency assays. The low effect on cell viability and proliferation in the dark was demonstrated by in vitro assays using L929 fibroblasts. The FCarbPc fostered the inhibition of Staphylococcus aureus strain, therefore demonstrating the platform's potential in the treatment of dermatological infections of microbial nature.
Databáze: MEDLINE