Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy.

Autor:	Matthies L; University Medical Center Hamburg-Eppendorf (UKE), Department of Oral and Maxillofacial Surgery, Martinistraße 52, D-20246 Hamburg, Germany.; These authors contributed equally., Gebrekidan MT; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen Graduate School in Advanced Optical Technologies (SAOT), Paul-Gordan-Straße 6, D-91054 Erlangen, Germany.; Technische Universität Bergakademie Freiberg (TUBAF), Institute of Thermal-, Environmental- and Resources' Process Engineering (ITUN), Leipziger Straße 28, D-09599 Freiberg, Germany.; These authors contributed equally., Tegtmeyer JF; University Medical Center Hamburg-Eppendorf (UKE), Department of Oral and Maxillofacial Surgery, Martinistraße 52, D-20246 Hamburg, Germany., Oetter N; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen Graduate School in Advanced Optical Technologies (SAOT), Paul-Gordan-Straße 6, D-91054 Erlangen, Germany.; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Oral and Maxillofacial Surgery, Glückstraße 11, D-91054 Erlangen, Germany., Rohde M; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Oral and Maxillofacial Surgery, Glückstraße 11, D-91054 Erlangen, Germany., Vollkommer T; University Medical Center Hamburg-Eppendorf (UKE), Department of Oral and Maxillofacial Surgery, Martinistraße 52, D-20246 Hamburg, Germany., Smeets R; University Medical Center Hamburg-Eppendorf (UKE), Department of Oral and Maxillofacial Surgery, Martinistraße 52, D-20246 Hamburg, Germany., Wilczak W; University Medical Center Hamburg-Eppendorf (UKE), Institute of Pathology, Martinistraße 52, D-20246 Hamburg, Germany., Stelzle F; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen Graduate School in Advanced Optical Technologies (SAOT), Paul-Gordan-Straße 6, D-91054 Erlangen, Germany.; Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Oral and Maxillofacial Surgery, Glückstraße 11, D-91054 Erlangen, Germany., Gosau M; University Medical Center Hamburg-Eppendorf (UKE), Department of Oral and Maxillofacial Surgery, Martinistraße 52, D-20246 Hamburg, Germany., Braeuer AS; Technische Universität Bergakademie Freiberg (TUBAF), Institute of Thermal-, Environmental- and Resources' Process Engineering (ITUN), Leipziger Straße 28, D-09599 Freiberg, Germany., Knipfer C; University Medical Center Hamburg-Eppendorf (UKE), Department of Oral and Maxillofacial Surgery, Martinistraße 52, D-20246 Hamburg, Germany.
Jazyk:	angličtina
Zdroj:	Biomedical optics express [Biomed Opt Express] 2021 Jan 13; Vol. 12 (2), pp. 836-851. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).
DOI:	10.1364/BOE.409456
Abstrakt:	Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers and frequently preceded by non-malignant lesions. Using Shifted-Excitation Raman Difference Spectroscopy (SERDS), principal component and linear discriminant analysis in native tissue specimens, 9500 raw Raman spectra of OSCC, 4300 of non-malignant lesions and 4200 of physiological mucosa were evaluated. Non-malignant lesions were distinguished from physiological mucosa with a classification accuracy of 95.3% (95.4% sensitivity, 95.2% specificity, area under the curve (AUC) 0.99). Discriminating OSCC from non-malignant lesions showed an accuracy of 88.4% (93.7% sensitivity, 76.7% specificity, AUC 0.93). OSCC was identified against physiological mucosa with an accuracy of 89.8% (93.7% sensitivity, 81.0% specificity, AUC 0.90). These findings underline the potential of SERDS for the diagnosis of oral cavity lesions. Competing Interests: The authors declare that there are no conflicts of interest related to this article. (© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.)
Databáze:	MEDLINE
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