Evolutionary Dynamics and Dissemination Pattern of the SARS-CoV-2 Lineage B.1.1.33 During the Early Pandemic Phase in Brazil.
| Autor: | Resende PC; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., Delatorre E; Departamento de Biologia, Centro de Ciencias Exatas, Naturais e da Saude, Universidade Federal do Espirito Santo, Alegre, Brazil., Gräf T; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil., Mir D; Unidad de Genomica y Bioinformatica, Centro Universitario Regional del Litoral Norte, Universidad de la Republica, Salto, Uruguay., Motta FC; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., Appolinario LR; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., da Paixão ACD; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., Mendonça ACDF; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., Ogrzewalska M; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., Caetano B; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., Wallau GL; Instituto Aggeu Magalhaes, Fundação Oswaldo Cruz, Recife, Brazil., Docena C; Instituto Aggeu Magalhaes, Fundação Oswaldo Cruz, Recife, Brazil., Dos Santos MC; Instituto Evandro Chagas, Belem, Para., de Almeida Ferreira J; Instituto Evandro Chagas, Belem, Para., Sousa Junior EC; Instituto Evandro Chagas, Belem, Para., da Silva SP; Instituto Evandro Chagas, Belem, Para., Fernandes SB; Laboratorio Central de Saude Publica do Estado de Santa Catarina (LACEN-SC), Florianopolis, Brazil., Vianna LA; Laboratorio Central de Saude Publica do Estado Espirito Santo (LACEN-ES), Vitoria, Brazil., Souza LDC; Laboratorio Central de Saude Publica do Distrito Federal (LACEN-DF), Brazilia, Brazil., Ferro JFG; Laboratorio Central de Saude Publica de Alagoas (LACEN-AL), Maceio, Brazil., Nardy VB; Laboratorio Central de Saude Publica da Bahia (LACEN-BA), Salvador, Brazil., Santos CA; Laboratorio Central de Saude Publica de Sergipe (LACEN-SE), Aracaju, Brazil., Riediger I; Laboratorio Central de Saude Publica de Parana (LACEN-PR), Curitiba, Brazil., do Carmo Debur M; Laboratorio Central de Saude Publica de Parana (LACEN-PR), Curitiba, Brazil., Croda J; Fiocruz Mato Grosso do Sul, Campo Grande, Brazil.; Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, Brazil., Oliveira WK; Hospital das Forças Armadas, Ministério da Defesa, Brasília, Brazil., Abreu A; Coordenadoria Geral de Laboratorios - Ministério da Saude, Brazilia, Brazil., Bello G; Laboratorio de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil., Siqueira MM; Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute (IOC), Oswaldo Cruz Foundation (FIOCRUZ), SARS-CoV-2 National Reference Laboratory for the Brazilian Ministry of Health (MoH) and Regional Reference Laboratory in Americas for the Pan-American Health Organization (PAHO/WHO), Rio de Janeiro, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in microbiology [Front Microbiol] 2021 Feb 17; Vol. 11, pp. 615280. Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2020). |
| DOI: | 10.3389/fmicb.2020.615280 |
| Abstrakt: | A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we investigated in more detail the origin of the major and most widely disseminated SARS-CoV-2 Brazilian lineage B.1.1.33. We recovered 190 whole viral genomes collected from 13 Brazilian states from February 29 to April 31, 2020 and combined them with other B.1.1 genomes collected globally. Our genomic survey confirms that lineage B.1.1.33 is responsible for a variable fraction of the community viral transmissions in Brazilian states, ranging from 2% of all SARS-CoV-2 genomes from Pernambuco to 80% of those from Rio de Janeiro. We detected a moderate prevalence (5-18%) of lineage B.1.1.33 in some South American countries and a very low prevalence (<1%) in North America, Europe, and Oceania. Our study reveals that lineage B.1.1.33 evolved from an ancestral clade, here designated B.1.1.33-like, that carries one of the two B.1.1.33 synapomorphic mutations. The B.1.1.33-like lineage may have been introduced from Europe or arose in Brazil in early February 2020 and a few weeks later gave origin to the lineage B.1.1.33. These SARS-CoV-2 lineages probably circulated during February 2020 and reached all Brazilian regions and multiple countries around the world by mid-March, before the implementation of air travel restrictions in Brazil. Our phylodynamic analysis also indicates that public health interventions were partially effective to control the expansion of lineage B.1.1.33 in Rio de Janeiro because its median effective reproductive number ( R Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Resende, Delatorre, Gräf, Mir, Motta, Appolinario, Paixão, Mendonça, Ogrzewalska, Caetano, Wallau, Docena, Santos, de Almeida Ferreira, Sousa Junior, Silva, Fernandes, Vianna, Souza, Ferro, Nardy, Santos, Riediger, do Carmo Debur, Croda, Oliveira, Abreu, Bello and Siqueira.) |
| Databáze: | MEDLINE |
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