Maternal Serum Melatonin Increases During Pregnancy and Falls Immediately After Delivery Implicating the Placenta as a Major Source of Melatonin.

Autor:	Ejaz H; Institute of Medical Science, University of Aberdeen, Aberdeen, United Kingdom.; Institute of Applied Health Science, University of Aberdeen, Aberdeen, United Kingdom., Figaro JK; Institute of Medical Science, University of Aberdeen, Aberdeen, United Kingdom.; Institute of Applied Health Science, University of Aberdeen, Aberdeen, United Kingdom., Woolner AMF; Institute of Applied Health Science, University of Aberdeen, Aberdeen, United Kingdom., Thottakam BMV; Institute of Medical Science, University of Aberdeen, Aberdeen, United Kingdom., Galley HF; Institute of Medical Science, University of Aberdeen, Aberdeen, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Feb 18; Vol. 11, pp. 623038. Date of Electronic Publication: 2021 Feb 18 (Print Publication: 2020).
DOI:	10.3389/fendo.2020.623038
Abstrakt:	Melatonin is a neuroendocrine hormone which regulates circadian rhythm and is also an antioxidant. The role of melatonin in pregnancy is emerging. The enzymes needed for endogenous synthesis of melatonin have been identified in the placenta, although the contribution to circulating maternal melatonin in normal pregnancy is unclear. This work aimed to determine serum levels of melatonin and its major metabolite 6-hydroxymelatonin sulfate (6-OHMS) in normal pregnant women during each trimester of pregnancy, and immediately after delivery. Blood samples were obtained from a cohort of healthy pregnant women during each trimester of pregnancy (n = 26), from women scheduled for elective Cesarean section (CS) before and after delivery (n = 15), along with placental samples, and from healthy non-pregnant women as controls (n = 30). Melatonin and its major metabolite, 6-OHMS, were measured using enzyme immunoassay. Levels of serum melatonin were significantly higher during pregnancy than in non-pregnant women (P = 0.025) and increased throughout pregnancy (P < 0.0001). In women undergoing CS, serum melatonin decreased markedly 24 h after delivery (P = 0.0013). Similar results were seen for serum levels of 6-OHMS, and placental tissue 6-OHMS levels correlated with week of gestation at delivery (p = 0.018). In summary, maternal melatonin production is higher in pregnant than in non-pregnant women, increases significantly during pregnancy with highest levels in the third trimester, and decreases abruptly after delivery. These results suggest that the placenta is a major source of melatonin and supports a physiological role for melatonin in pregnancy. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Ejaz, Figaro, Woolner, Thottakam and Galley.)
Databáze:	MEDLINE
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