The Neural Correlates of Cued Reward Omission.

Autor:	Mollick JA; Department of Psychiatry, Yale University, New Haven, CT, United States., Chang LJ; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States., Krishnan A; Department of Psychology, Brooklyn College, City University of New York, Brooklyn, NY, United States., Hazy TE; eCortex, Inc, Boulder, CO, United States., Krueger KA; eCortex, Inc, Boulder, CO, United States., Frank GKW; UCSD Eating Disorder Center for Treatment and Research, University of California, San Diego, San Diego, CA, United States., Wager TD; Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, United States., O'Reilly RC; Department of Psychology and Computer Science Center for Neuroscience, University of California, Davis, Davis, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2021 Feb 11; Vol. 15, pp. 615313. Date of Electronic Publication: 2021 Feb 11 (Print Publication: 2021).
DOI:	10.3389/fnhum.2021.615313
Abstrakt:	Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla-Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor (CI). Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. Competing Interests: RO’R is CSO and JM, TH, and KK are researchers at eCortex, Inc., Boulder, CO, United States, which may derive indirect benefit from the work presented here. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Mollick, Chang, Krishnan, Hazy, Krueger, Frank, Wager and O’Reilly.)
Databáze:	MEDLINE
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