The role of CD68+ and CD163+ macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions.

Autor: Ferrisse TM; Oral Medicine, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil. Electronic address: tuliomferrisse@gmail.com., de Oliveira AB; Department of Orthodontics and Pediatric Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., Palaçon MP; Oral Medicine, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., Silva EV; Oral Medicine, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., Massucato EMS; Oral Medicine, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil., de Almeida LY; Department of Pathology and Forensic Medicine, Ribeirão Preto Medical Scholl (FMRP/USP), University of São Paulo, Ribeirão Preto, Brazil., Léon JE; Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Café, S/N, Ribeirão Preto, São Paulo 14040-904, Brazil. Electronic address: jleon@forp.usp.br., Bufalino A; Oral Medicine, Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Immunobiology [Immunobiology] 2021 May; Vol. 226 (3), pp. 152072. Date of Electronic Publication: 2021 Feb 23.
DOI: 10.1016/j.imbio.2021.152072
Abstrakt: Macrophages are phagocytic cells with essential participation in immunological events of the oral cavity. However, the role of these cells in oral lichen planus (OLP) and oral lichenoid lesions (OLL) remains unclear. The present study aimed to evaluate the density of macrophages in OLP and OLL, and to compare it with that of oral inflammatory fibrous hyperplasia (OIFH) (control group). 14 cases of OLP, 14 cases of OLL and 14 cases of OIFH were selected for immunohistochemical analysis of CD68 + (M1) and CD163 + (M2) macrophage expression. CD68 + and CD163 + macrophages densities were measured in the intraepithelial and subepithelial areas. The statistical tests used were multivariate analysis of variance, as well as a correlation and linear regression. OLP has more CD68+ macrophages when comparing with OLL (p = 0.001) and OIFH (p = 0.045). There is a very strong relationship between the macrophages types (p < 0.0001) in OLP and OLL. The linear regression showed that to OLL development (p < 0.0001/R 2'  = 0.9584), the presence of different types of macrophages are more essential than to OLP (p < 0.0001/R 2'  = 0.8983). However, in the OLP these dependencies are also largely. CD68 + macrophages may be associated with immunopathogenesis of OLP, indicating a pro-inflammatory activity and regulatory role in the type of T-cell response. Besides, CD68 + macrophages can cooperate in the diagnosis of OLP. These results are essential to future studies that seek a therapeutic target for OLP and OLL.
(Copyright © 2021 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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