Emergence of a Severe Acute Respiratory Syndrome Coronavirus 2 Virus Variant With Novel Genomic Architecture in Hong Kong.

Autor:	Tse H; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China., Lung DC; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China.; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., Wong SC; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China., Ip KF; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China., Wu TC; Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., To KK; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China., Kok KH; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China., Yuen KY; State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China., Choi GK; Department of Pathology, Hong Kong Children's Hospital, Hong Kong Special Administrative Region, China.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Nov 02; Vol. 73 (9), pp. 1696-1699.
DOI:	10.1093/cid/ciab198
Abstrakt:	Throughout the coronavirus disease 2019 (COVID-19) pandemic, divergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have emerged continuously, mostly through the genomic accumulation of substitutions. We report the discovery of a SARS-CoV-2 variant with a novel genomic architecture characterized by absent ORF7a, ORF7b, and ORF8, and a C-terminally modified ORF6 product resulting from partial 5'-untranslated region (UTR) duplication and transposition. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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