The effects of MDR/RR-TB treatment on HIV disease: A systematic review of literature.

Autor: Geiger K; School of Nursing, Johns Hopkins University, Baltimore, MD, United States of America., Stamper PD; School of Nursing, Johns Hopkins University, Baltimore, MD, United States of America., Farley JE; School of Nursing, Johns Hopkins University, Baltimore, MD, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Mar 05; Vol. 16 (3), pp. e0248174. Date of Electronic Publication: 2021 Mar 05 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0248174
Abstrakt: Background: Multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB) and human immunodeficiency virus (HIV) co-infection are a deadly combination. While evidence on the effects of HIV co-infection on MDR/RR-TB treatment outcomes is well-documented, little published evidence describes the effects of MDR/RR-TB treatment on HIV disease.
Methods: We conducted a review of literature published prior to June 2020. We searched Pubmed, CINAHL, and EMBASE using variations of the terms "multidrug-resistant tuberculosis," "HIV," and either "CD4" or "viral load." Two reviewers independently completed title and abstract screening, full-text screening, article evaluation, and data extraction. We also included five published articles evaluated as evidence by the World Health Organization (WHO) in preparation for the 2019 MDR/RR-TB treatment guideline update.
Results: A total of 459 references were returned, with 362 remaining after duplicate removal. Following article screening, six manuscripts were included. Articles reported CD4 count and/or viral load results for MDR/RR-TB and HIV co-infected patients during and/or after MDR/RR-TB treatment. The additional five references identified from the WHO guideline revision did not report HIV disease indicators after MDR/RR-TB initiation.
Conclusion: There is a paucity of evidence on HIV disease indicators following MDR/RR-TB treatment. Researchers should report longitudinal HIV disease indicators in co-infected patients in publications.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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