[Killer immunoglobulin-like receptor and cancer].

Autor:	Gómez-Luque JM; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, España., Urrutia-Maldonado E; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, España., Muñoz de Rueda P; Instituto de Investigación Biosanitaria de Granada, Granada, España., Abril-Molina A; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, España., Ocete-Hita E; Hospital Universitario Materno Infantil Virgen de las Nieves, Granada, España; Instituto de Investigación Biosanitaria de Granada, Granada, España; Universidad de Granada, Granada, España. Electronic address: estherocete@ugr.es.
Jazyk:	Spanish; Castilian
Zdroj:	Anales de pediatria [An Pediatr (Engl Ed)] 2021 Mar 01. Date of Electronic Publication: 2021 Mar 01.
DOI:	10.1016/j.anpedi.2021.02.001
Abstrakt:	Introduction: Natural killer (NK) cells play an important role in defense against tumor cells. The development and function of NK cells is governed by a dynamic balance between inhibition and activation of cell surface receptors, including KIR receptors. Patients and Method: A case-control study is carried out that compares a group of 46 children diagnosed with malignant diseases, the control group is made up of 82 healthy children. KIRs genes, haplotypes and ligands were determined and compared between groups. Results: There are no differences in KIRs genes, KIRs haplotypes or in KIRs gene ligands between groups. However, when KIRS and ligands were jointly studied, k2DS1_C2 was significantly higher in the group of cancer children (p̊=̊0.016). Conclusions: Our results do not provide evidence of an association between pediatric cancer disease with genotypes and groups of genes KIRs. The k2DS1_C2 genotype could predispose to susceptibility to malignant processes in children. (Copyright © 2021. Publicado por Elsevier España, S.L.U.)
Databáze:	MEDLINE
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