| Autor: |
Wang DL; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Song HD; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Hao QP; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Fang JX; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Liu B; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Zhou JR; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Jiao F; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Fan CG; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China., Liu R; Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2021 Feb 28; Vol. 43 (1), pp. 32-36. |
| DOI: |
10.3881/j.issn.1000-503X.13399 |
| Abstrakt: |
Objective To evaluate the effect of methylprednisolone sodium succinate combined with tropisetron on postoperative nausea and vomiting(PONV)under microvascular decompression of hemifacial spasm.Methods From January to June 2019,485 patients undergoing microvascular decompression for facial spasm at Department of Neurosurgery,Peking University People's Hospital were randomly assigned into two groups with random number table method.For group A(n=242),2 ml saline was administrated by intravenous drip before induction and 5 mg tropisetron after operation.For group B(n=243),40 mg methylprednisolone sodium succinate was administrated by intravenous drip before induction and 5 mg tropisetron after operation.The anesthesia time,operation time,and incidence of PONV in 0-24 h and 24-48 h were recorded for the comparison of the remedial treatment rate of nausea and vomiting between the two groups.Results There was no significant difference in age,gender,smoking history,body mass index value,American Society of Anesthesiologists score,medical history,surgical side,PONV history,operation time or anesthesia time between the two groups(all P > 0.05).The incidence of PONV in group A was 35.5% and 18.2% during 0-24 h and 24-48 h,respectively,which was significantly higher than that(18.5%,χ 2 =7.331,P=0.007;8.2%,χ 2 =4.364,P=0.037)in group B.The application rate of antiemetic drugs in group A was 15.2% and 8.7% during 0-24 h and 24-48 h,respectively,which was significantly higher than that(5.3%,χ 2 =5.327,P=0.021;2.0%,χ 2 =4.432,P=0.035)in group B.Conclusion The combination of methylprednisolone sodium succinate and tropisetron can effectively prevent PONV under microvascular decompression of hemifacial spasm,with the performance superior to single drug treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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