Development of membranes based on carboxymethyl cellulose/acetylated arrowroot starch containing bromelain extract carried on nanoparticles and liposomes.

Autor:	Miranda ÍKSPB; Health Department, State University of Feira de Santana, Av. Transnordestina, s/n - Novo Horizonte, Feira de Santana - BA, Brazil, CEP 44036-900., Santana FR; Health Department, State University of Feira de Santana, Av. Transnordestina, s/n - Novo Horizonte, Feira de Santana - BA, Brazil, CEP 44036-900., Camilloto GP; Technology Department, State University of Feira de Santana, Av. Transnordestina, s/n - Novo Horizonte, Feira de Santana - BA, Brazil, CEP 44036-900., Detoni CB; Pharmacy Department - Campus Macaé, Federal University of Rio de Janeiro, Av. Aluizio da Silva Gomes, 50 - Novo Cavaleiros, Macaé - RJ, Brazil, CEP 27930-560., Souza FVD; EMBRAPA - Empresa Brasileira de Pesquisa Agropecuária, R. Embrapa, s/n - Chapadinha, Cruz das Almas - BA, Brazil, CEP 44380-000., Cabral-Albuquerque ECM; Federal University of Bahia, R. Prof. Aristídes Novis, 2 - Federação, Salvador - BA, Brazil, CEP 40210-630., Alves SL; Health Department, State University of Feira de Santana, Av. Transnordestina, s/n - Novo Horizonte, Feira de Santana - BA, Brazil, CEP 44036-900., Neco GL; Health Department, State University of Feira de Santana, Av. Transnordestina, s/n - Novo Horizonte, Feira de Santana - BA, Brazil, CEP 44036-900., Lima FO; Health Department, State University of Feira de Santana, Av. Transnordestina, s/n - Novo Horizonte, Feira de Santana - BA, Brazil, CEP 44036-900., Assis SA; Health Department, State University of Feira de Santana, Av. Transnordestina, s/n - Novo Horizonte, Feira de Santana - BA, Brazil, CEP 44036-900. Electronic address: sandraassis@uefs.br.
Jazyk:	angličtina
Zdroj:	Journal of pharmaceutical sciences [J Pharm Sci] 2021 Jun; Vol. 110 (6), pp. 2372-2378. Date of Electronic Publication: 2021 Mar 01.
DOI:	10.1016/j.xphs.2021.02.031
Abstrakt:	Polymeric membranes have been used in several applications, including their use as curatives in cutaneous wounds. Bromelain has long been used for anti-inflammatory purposes, so the objective of this work was to produce carboxymethylcellulose-acetylated blends, incorporate bromelain, characterize the systems, compare the blends with bromelain loaded in nanoparticles and liposomes and, finally, to evaluate their healing potential. Four membrane formulations were produced by solvent evaporation: the control, membranes containing free bromelain, bromelain-loaded nanoparticles (NPs) and bromelain-loaded liposomes (LIPs). The enzyme concentration was the same for all formulations. Transparent, flexible and intact films were obtained. The membranes containing free bromelain, bromelain-loaded NPs and bromelain-loaded LIPs had higher water content, lower water vapor permeability and maximum tensile strength, and greater elongation at rupture. The capacity to absorb simulated exudate was higher in samples containing free bromelain, and bioadhesion was reduced in the presence of free bromelain compared to the control. An in vivo assay was performed to verify the membranes' healing potential. Histological analysis revealed no edema on the 14th day in animals treated with membranes containing bromelain-loaded NPs and LIPs. (Copyright © 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu