Differences in intestinal microbiota profiling after upper and lower gastrointestinal surgery.

Autor:	Lin XH; Department of Medicine, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan, ROC.; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC., Yang UC; School of Medicine, Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC., Luo JC; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Department of Medicine, Keelung Hospital, Ministry of Health Welfare, Keelung, Taiwan, ROC., Chang TE; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Lin HH; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of Colon and Rectal Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Huang CW; School of Medicine, Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC., Chiou JJ; School of Medicine, Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC., Fang WL; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Huang KH; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Huang YH; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Hou MC; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Lee FY; Department of Medicine, National Yang Ming Chiao Tung University, School of Medicine, Taipei, Taiwan, ROC.; Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Jazyk:	angličtina
Zdroj:	Journal of the Chinese Medical Association : JCMA [J Chin Med Assoc] 2021 Apr 01; Vol. 84 (4), pp. 354-360.
DOI:	10.1097/JCMA.0000000000000510
Abstrakt:	Background: We aimed to investigate the long-term effects of metabolic profiles and microbiota status in patients after upper gastrointestinal (GI) surgery and lower GI surgery and compared them with a control group. Methods: In this cross-sectional study, we analyzed the occurrence of metabolic syndrome (MS) in 10 patients who underwent curative total gastrectomy with Roux-en-Y esophagojejunostomy (RYEJ) anastomosis, 11 patients who underwent curative partial colectomy with right hemicolectomy (RH), and 33 age- and sex-matched controls. Fecal samples were also analyzed by a next-generation sequencing method. Results: Compared with the control group, the occurrence of MS was significantly lower among patients who underwent total gastrectomy with RYEJ than the controls over the long-term follow-up (>8 years; p < 0.05). Patients who received RH only had a trend of higher serum fasting glucose (p = 0.10). The diversity of the gut microbiota significantly decreased after RH in comparison with the control group and RYEJ group, respectively (p < 0.05). Principal component analysis revealed significant differences between the control, RYEJ, and RH groups (p < 0.001). At the genus level, the ratio of Prevotella to Bacteroides (P/B) was significantly higher in the RYEJ group than in the control group, whereas the P/B ratio was significantly lower in the RH group than in the control group (p < 0.05). Conclusion: Early gastric cancer patients who received total gastrectomy with RYEJ had a lower occurrence of MS than the controls, while early colorectal cancer patients who received RH were associated with a higher serum fasting glucose than the controls during long-term follow-up. In parallel with the metabolic differences, the P/B ratio was also significantly altered in patients after upper and lower GI surgery. Competing Interests: Conflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article. (Copyright © 2021, the Chinese Medical Association.)
Databáze:	MEDLINE
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