Anti-Leishmania activity of extracts from Piper cabralanum C.DC. (Piperaceae).

Autor: Valéria Amorim L; Antileishmania Activity Laboratory, Federal University of Piauí, Teresina, Piauí, Brazil., de Lima Moreira D; Natural Products Laboratory, Institute of Pharmaceutical Tecnologies, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro-RJ, Brazil., Muálem de Moraes Alves M; Antileishmania Activity Laboratory, Federal University of Piauí, Teresina, Piauí, Brazil., Jessé Ramos Y; Natural Products Laboratory, Institute of Pharmaceutical Tecnologies, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro-RJ, Brazil., Pereira Costa Sobrinho E; Antileishmania Activity Laboratory, Federal University of Piauí, Teresina, Piauí, Brazil., Arcanjo DDR; Department of Biophysics and Physiology, Laboratory of Funcional and Molecular Studies in Physiopharmacology, Federal University of Piauí, Teresina, Piauí, Brazil., Rodrigues de Araújo A; Research Center on Biodiversity and Biotechnology, BIOTEC, Federal University of Delta of Parnaíba, UFDPar, Parnaíba, Piauí, Brazil., de Souza de Almeida Leite JR; Center for Research in Applied Morphology and Immunology, NuPMIA, University of Brasilia, Brasilia, Brazil., das Chagas Pereira de Andrade F; Department of Biophysics and Physiology, Laboratory of Innovation on Science and Technology, Federal University of Piauí, Teresina, Piauí, Brazil., Mendes AN; Department of Biophysics and Physiology, Laboratory of Innovation on Science and Technology, Federal University of Piauí, Teresina, Piauí, Brazil., Aécio de Amorim Carvalho F; Antileishmania Activity Laboratory, Federal University of Piauí, Teresina, Piauí, Brazil.
Jazyk: angličtina
Zdroj: Zeitschrift fur Naturforschung. C, Journal of biosciences [Z Naturforsch C J Biosci] 2021 Mar 02; Vol. 76 (5-6), pp. 229-241. Date of Electronic Publication: 2021 Mar 02 (Print Publication: 2021).
DOI: 10.1515/znc-2020-0284
Abstrakt: Species of Piperaceae are known by biological properties, including antiparasitic such as leishmanicidal, antimalarial and in the treatment of schistosomiasis. The aim of this work was to evaluate the antileishmania activity, cytotoxic effect, and macrophage activation patterns of the methanol (MeOH), hexane (HEX), dichloromethane (DCM) and ethyl acetate (EtOAc) extract fractions from the leaves of Piper cabralanum C.DC. The MeOH, HEX and DCM fractions inhibited Leishmanina amazonensis promastigote-like forms growth with a half maximal inhibitory concentration (IC 50 ) of 144.54, 59.92, and 64.87 μg/mL, respectively. The EtOAc fraction did not show any relevant activity. The half maximal cytotoxic concentration (CC 50 ) for macrophages were determined as 370.70, 83.99, 113.68 and 607 μg/mL for the MeOH, HEX and DCM fractions, respectively. The macrophage infectivity was concentration-dependent, especially for HEX and DCM. MeOH, HEX and DCM fractions showed activity against L. amazonensis with low cytotoxicity to murine macrophages and lowering infectivity by the parasite. Our results provide support for in vivo studies related to a potential application of P. cabralanum extract and fractions as a promising natural resource in the treatment of leishmaniasis.
(© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze: MEDLINE
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