Can new immunoassay techniques improve bladder cancer diagnostics With protein biomarkers?
| Autor: | Shlyapnikov YM; Institute of Theoretical and Experimental Biophysics RAS, Pushchino, Russia., Malakhova EA; Institute of Theoretical and Experimental Biophysics RAS, Pushchino, Russia., Vinarov AZ; Institute for Urology and Reproductive Health, Sechenov First Moscow State Medical University, Moscow, Russia., Zamyatnin AA Jr; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia.; Department of Biotechnology, Sirius University of Science and Technology, Sochi, Russia., Shlyapnikova EA; Institute of Theoretical and Experimental Biophysics RAS, Pushchino, Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in molecular biosciences [Front Mol Biosci] 2021 Feb 15; Vol. 7, pp. 620687. Date of Electronic Publication: 2021 Feb 15 (Print Publication: 2020). |
| DOI: | 10.3389/fmolb.2020.620687 |
| Abstrakt: | The search for new diagnostic tests for cancer or ways to improve existing tests is primarily driven by the desire to identify the disease as early as possible. In this report, we summarize the current knowledge of the most promising diagnostic protein bladder cancer (BC) markers reported over the last decade. Unfortunately, analysis of published data suggests that a reliable, highly sensitive biomarker test-system based on ELISA for detecting BC has not yet been developed. The use of more sensitive assays to detect ultra-low concentrations of biomarkers not available for ELISA, could be very beneficial. Based on the literature and pilot experimental data, we conclude that a highly sensitive immunoassay using microarrays and magnetic labels, could be an effective and cheap technique suitable for the detection of diagnostically relevant BC biomarkers. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Shlyapnikov, Malakhova, Vinarov, Zamyatnin and Shlyapnikova.) |
| Databáze: | MEDLINE |
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