Osteogenic potential of dental and oral derived stem cells in bone tissue engineering among animal models: An update.

Autor: Berbéri A; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Lebanese University, Beirut, Lebanon. Electronic address: aberberi@ul.edu.lb., Fayyad-Kazan M; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon; Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences-I, Lebanese University, Hadath- Beirut, Lebanon. Electronic address: mfayyadk@gmail.com., Ayoub S; Department of Prosthodontics, Faculty of Dentistry, Lebanese University, Beirut, Lebanon. Electronic address: sara.ayoub.1@ul.edu.lb., Bou Assaf R; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Lebanese University, Beirut, Lebanon. Electronic address: rbouassaf@gmail.com., Sabbagh J; Department of Restorative Dentistry and Endodontics, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon. Electronic address: josephsabbagh@hotmail.com., Ghassibe-Sabbagh M; Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Beirut, Lebanon. Electronic address: michella.sabbagh@lau.edu.lb., Badran B; Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences-I, Lebanese University, Hadath- Beirut, Lebanon. Electronic address: bassam.badran@ul.edu.lb.
Jazyk: angličtina
Zdroj: Tissue & cell [Tissue Cell] 2021 Aug; Vol. 71, pp. 101515. Date of Electronic Publication: 2021 Feb 24.
DOI: 10.1016/j.tice.2021.101515
Abstrakt: Small bone defects can heal spontaneously through the bone modeling process due to their physiological environmental conditions. The bone modeling cycle preserves the reliability of the skeleton through the well-adjusted activities of its fundamental cell. Stem cells are a source of pluripotent cells with a capacity to differentiate into any tissue in the existence of a suitable medium. The concept of bone engineering is based on stem cells that can differentiate into bone cells. Mesenchymal stromal cells have been evaluated in bone tissue engineering due to their capacity to differentiate in osteoblasts. They can be isolated from bone marrow and from several adults oral and dental tissues such as permanent or deciduous teeth dental pulp, periodontal ligament, apical dental papilla, dental follicle precursor cells usually isolated from the follicle surrounding the third molar, gingival tissue, periosteum-derived cells, dental alveolar socket, and maxillary sinus Schneiderian membrane-derived cells. Therefore, a suitable animal model is a crucial step, as preclinical trials, to study the outcomes of mesenchymal cells on the healing of bone defects. We will discuss, through this paper, the use of mesenchymal stem cells obtained from several oral tissues mixed with different types of scaffolds tested in different animal models for bone tissue engineering. We will explore and link the comparisons between human and animal models and emphasized the factors that we need to take into consideration when choosing animals. The pig is considered as the animal of choice when testing large size and multiple defects for bone tissue engineering.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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