| Autor: |
Lee CR; Laboratoires d'Etudes et de Recherches Synthélabo (LERS), Bagneux, France., Esnaud H |
| Jazyk: |
angličtina |
| Zdroj: |
Biomedical & environmental mass spectrometry [Biomed Environ Mass Spectrom] 1988 Mar 01; Vol. 15 (5), pp. 249-52. |
| DOI: |
10.1002/bms.1200150503 |
| Abstrakt: |
Determination of the low concentrations (less than 10-100 pg ml-1) of melatonin in blood plasma by gas chromatography/mass spectrometry has previously required the use of negative ionization (electron capture) mass spectrometry, a technique particularly delicate to set up. We show that a general-purpose medium-resolution instrument gives adequate sensitivity in electron impact mode, when used with a capillary gas chromatographic column-switching device. A straightforward extraction procedure gives good specificity, and the limit of useful measurement is better than 10 pg per 1 ml sample. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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