Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies.

Autor: Povsic TJ; Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA., Sanz-Ruiz R; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERCV, Madrid, Spain., Climent AM; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERCV, Madrid, Spain., Bolli R; Department of Medicine, School of Medicine, University of Louisville, Louisville, KY, USA., Taylor DA; Center for Cell and Organ Biotechnology, Texas Heart Institute, Houston, TX, USA., Gersh BJ; Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA., Menasché P; Department of Cardiovascular Surgery, Georges Pompidou European Hospital, Paris, France., Perin EC; Center for Clinical Research, Texas Heart Institute, Houston, TX, USA., Pompilio G; Vascular Biology and Regenerative Medicine Unit and Dept. of Cardiovascular Surgery, Centro Cardiologico Monzino IRCCS, Milan, Italy., Atsma DE; Faculteit der Sociale Wetenschappen, Instituut Psychologie, Gezondheids, Medische-Neuropsychologie, Leiden, The Netherlands., Badimon L; Cardiovascular Program (ICCC), IR Hospital de la Santa Creu i Sant Pau, CIBERCV, Barcelona, Spain., DeMaria AN; Sulpizio Cardiovascular Center, UC San Diego Health, San Diego, CA, USA., Hare JM; Interdisciplinary Stem Cell Institute and Division of Cardiology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA., Henry TD; The Carl and Edyth Lindner Center for Research and Education, The Christ Hospital, Cincinnati, OH, USA., Janssens S; Centre for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Kastrup J; Department of Cardiology, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Rigshospitalet, Copenhagen, Denmark., Torella D; Molecular and Cellular Cardiology LAB, Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy., Traverse JH; Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, MN, USA., Willerson JT; Center for Clinical Research, Texas Heart Institute, Houston, TX, USA., Fernández-Avilés F; Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CIBERCV, Madrid, Spain.
Jazyk: angličtina
Zdroj: ESC heart failure [ESC Heart Fail] 2021 Jun; Vol. 8 (3), pp. 2306-2309. Date of Electronic Publication: 2021 Mar 02.
DOI: 10.1002/ehf2.13256
Abstrakt: The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, determine what can be learned from past mistakes, and formulate best practices for future work. This special communication summarizes an introspective assessment of what has fallen short, how to prevent similar issues, and how the field might best move forward in the service of science and patients.
(© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Databáze: MEDLINE
Externí odkaz: