| Autor: |
Horn-Brahimi MC; C.S.I.R.O., Division of Protein Chemistry, Parkville, Victoria, Australia., Breton M, Berrou E, Deudon E, Picard J |
| Jazyk: |
angličtina |
| Zdroj: |
Artery [Artery] 1988; Vol. 15 (3), pp. 122-39. |
| Abstrakt: |
The role of proteoglycans in the binding of 125I-labeled low-density lipoproteins (LDL) to cultured arterial smooth muscle cells was examined. About 60% of cell bound 125I-labeled LDL could be released by unlabeled LDL, heparin, dextran sulfate or proteoglycan. Binding of 125I-labeled LDL decreased by about 50% when incubated in the presence of exogenous arterial proteoglycans. Exposure of cell cultures to rho-nitrophenyl-beta-D xyloside resulted in a 40% decrease in both the amount of 35S-labeled proteoglycan in the cell layer and the 125I-labeled LDL binding, without modifying significantly the cell number and amount of cell layer protein. These data suggest that cell surface and/or cell matrix proteoglycans may influence binding of LDL to either specific receptor or non-receptor sites and thereby play a role in the intracellular deposition of lipid in the arterial wall. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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