Endodontic set sealer eluates promote cytokine production in human mononuclear and periodontal ligament cells.

Autor: Pérez-Serrano RM; Endodontic Specialization Program, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico.; Laboratorio de Investigación Odontológica Multidisciplinaria, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Queretaro, Mexico., Soza-Bolaños AI; Endodontic Specialization Program, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico., Castillo-Valdés SN; Endodontic Specialization Program, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico., Hernández-Valdez G; Endodontic Specialization Program, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico., Mora-Izaguirre O; Laboratorio de Rumiología y Metabolismo Nutrición-FESC-UNAM, Juriquilla, Mexico., González-Dávalos ML; Laboratorio de Rumiología y Metabolismo Nutrición-FESC-UNAM, Juriquilla, Mexico., Dammaschke T; Department of Periodontology and Operative Dentistry, Westphalian Wilhelms-University, Münster, Germany., Domínguez-Pérez RA; Endodontic Specialization Program, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Querétaro, Mexico.; Laboratorio de Investigación Odontológica Multidisciplinaria, Facultad de Medicina, Universidad Autónoma de Querétaro, Santiago de Queretaro, Mexico.
Jazyk: angličtina
Zdroj: Australian endodontic journal : the journal of the Australian Society of Endodontology Inc [Aust Endod J] 2021 Dec; Vol. 47 (3), pp. 415-422. Date of Electronic Publication: 2021 Mar 02.
DOI: 10.1111/aej.12493
Abstrakt: Endodontic freshly mixed sealers display toxic effects; however, these are significantly reduced and most become relatively inert in the set state but there is no information about the possible inflammatory reaction promoted by them. Four contemporary and different formulated endodontic set sealers (MTA Fillapex, BioRoot RCS, AH Plus, and Pulp Canal Sealer) were evaluated. Human periodontal ligament cells and human peripheral blood mononuclear cells were stimulated for 3, 6, 12 and 24 h. Interleukin-6, tumour necrosis factor-alpha, interleukin-8 and interleukin-10 concentrations were measured by enzyme-linked immunosorbent assay. All endodontic set sealer eluates promoted a similar production (P ˃ 0.05) of the four cytokines. However, their concentrations decreased within a short time period to nearly undetectable concentrations after 24 h, suggesting that the studied endodontic set sealers do not possess inflammatory properties which has favoured their long-term use in clinical practice.
(© 2021 Australian Society of Endodontology Inc.)
Databáze: MEDLINE
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