Race, Genetic Admixture, and Cognitive Performance in the Cuban Population.

Autor:	Llibre-Guerra JJ; Department of Neurology, Washington University in St. Louis, MO, USA.; Global Brain Health Institute, University of California, San Francisco, USA., Li Y; Department of Neurology, Washington University in St. Louis, MO, USA., Allen IE; Department of Epidemiology & Biostatistics, University of California, San Francisco, USA., Llibre-Guerra JC; Department of Neurology, Hospital del Mar, Barcelona, Spain., Rodríguez Salgado AM; Global Brain Health Institute, University of California, San Francisco, USA., Peñalver AI; Department of Neurology, National Institute of Neurology and Neurosurgery, La Havana, Cuba., Almirall Sanchez A; Global Brain Health Institute, University of California, San Francisco, USA., Yokoyama JS; Global Brain Health Institute, University of California, San Francisco, USA.; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA., Grinberg L; Global Brain Health Institute, University of California, San Francisco, USA.; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA., Valcour V; Global Brain Health Institute, University of California, San Francisco, USA.; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA., Miller BL; Global Brain Health Institute, University of California, San Francisco, USA.; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California, San Francisco, USA., Llibre-Rodríguez JJ; Alzheimer Research Center, Havana School of Medicine, Cuba.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2022 Feb 03; Vol. 77 (2), pp. 331-338.
DOI:	10.1093/gerona/glab063
Abstrakt:	Background: Population aging will lead to a dramatic increase in dementia prevalence, which will disproportionally affect racial minorities. The presence of racial differences in dementia prevalence has been widely reported in United States, but there are no relevant studies on this topic in low- and middle-income countries. Methods: In a cross-sectional survey, 2944 older Cubans were recruited at a community-based level aimed to identify the effects of self-identified race and genetic admixture on cognitive performance. Dementia diagnosis was established using 10/66 Dementia and DSM-IV criteria. APOE-ε4 genotype was determined in 2511 (85%) and genetic admixture was completed for all dementia cases and in a randomly selected sample of cognitive healthy participants (218 dementia cases and 367 participants without dementia). Results: The overall prevalence of dementia was 8.7%, without large or statistically significant differences on dementia prevalence (p = .12) by self-identified race. Mean cognitive scores were similar across racial groups (p = .46). After controlling for age, sex, and education, greater proportion of African ancestry was not associated with cognitive performance (p = .17). Conclusions: We found no evidence of an independent effect of self-identified race and/or population ancestry on dementia prevalence or cognitive performance. This suggests that observed differences in dementia prevalence among diverse populations may be driven primarily by social determinants of health. (© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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