Cerebral functional networks during sleep in young and older individuals.

Autor: Daneault V; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada.; Center for Advanced Research in Sleep Medicine (CARSM), Hôpital du Sacré-Cœur de Montréal, 5400 Gouin Boulevard West, Montreal, QC, H4J 1C5, Canada.; Department of Psychology, University of Montreal, Downtown Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada., Orban P; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada.; Department of Psychiatry, University of Montreal, Downtown Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada.; Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, 7331 Hochelaga, Montreal, QC, H1N 3V2, Canada., Martin N; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada.; Center for Advanced Research in Sleep Medicine (CARSM), Hôpital du Sacré-Cœur de Montréal, 5400 Gouin Boulevard West, Montreal, QC, H4J 1C5, Canada.; Department of Psychology, University of Montreal, Downtown Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada., Dansereau C; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada., Godbout J; Center for Advanced Research in Sleep Medicine (CARSM), Hôpital du Sacré-Cœur de Montréal, 5400 Gouin Boulevard West, Montreal, QC, H4J 1C5, Canada.; Génie Électrique, École de technologie supérieure, 1100, rue Notre-Dame Ouest, Montreal, QC, H3C 1K3, Canada., Pouliot P; École Polytechnique de Montréal, Succursale Centre-Ville, C.P. 6079, Montreal, QC, H3C 3A7, Canada., Dickinson P; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada., Gosselin N; Center for Advanced Research in Sleep Medicine (CARSM), Hôpital du Sacré-Cœur de Montréal, 5400 Gouin Boulevard West, Montreal, QC, H4J 1C5, Canada.; Department of Psychology, University of Montreal, Downtown Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada., Vandewalle G; GIGA-Cyclotron Research Centre-In Vivo Imaging, Université de Liège, Allée du 6 Août, Bâtiment B30, Sart Tilman, 4000, Liège, Belgium., Maquet P; GIGA-Cyclotron Research Centre-In Vivo Imaging, Université de Liège, Allée du 6 Août, Bâtiment B30, Sart Tilman, 4000, Liège, Belgium., Lina JM; Génie Électrique, École de technologie supérieure, 1100, rue Notre-Dame Ouest, Montreal, QC, H3C 1K3, Canada.; Centre de Recherches Mathématiques (CRM), Université de Montréal, Succursale Centre-Ville, Case postale 6128, Montreal, QC, H3C 3J7, Canada.; Biomedical Engineering Department, McGill University, 3775 University Street, Montreal, QC, H3A 2B4, Canada.; U678 INSERM, Paris, France., Doyon J; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada., Bellec P; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada., Carrier J; Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen-Mary Road, Montreal, QC, H3W 1W5, Canada. julie.carrier.1@umontreal.ca.; Center for Advanced Research in Sleep Medicine (CARSM), Hôpital du Sacré-Cœur de Montréal, 5400 Gouin Boulevard West, Montreal, QC, H4J 1C5, Canada. julie.carrier.1@umontreal.ca.; Department of Psychology, University of Montreal, Downtown Station, P.O. Box 6128, Montreal, QC, H3C 3J7, Canada. julie.carrier.1@umontreal.ca.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Mar 01; Vol. 11 (1), pp. 4905. Date of Electronic Publication: 2021 Mar 01.
DOI: 10.1038/s41598-021-84417-0
Abstrakt: Even though sleep modification is a hallmark of the aging process, age-related changes in functional connectivity using functional Magnetic Resonance Imaging (fMRI) during sleep, remain unknown. Here, we combined electroencephalography and fMRI to examine functional connectivity differences between wakefulness and light sleep stages (N1 and N2 stages) in 16 young (23.1 ± 3.3y; 7 women), and 14 older individuals (59.6 ± 5.7y; 8 women). Results revealed extended, distributed (inter-between) and local (intra-within) decreases in network connectivity during sleep both in young and older individuals. However, compared to the young participants, older individuals showed lower decreases in connectivity or even increases in connectivity between thalamus/basal ganglia and several cerebral regions as well as between frontal regions of various networks. These findings reflect a reduced ability of the older brain to disconnect during sleep that may impede optimal disengagement for loss of responsiveness, enhanced lighter and fragmented sleep, and contribute to age effects on sleep-dependent brain plasticity.
Databáze: MEDLINE
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