Genome editing reveals fitness effects of a gene for sexual dichromatism in Sulawesian fishes.

Autor: Ansai S; Ecological Genetics Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Shizuoka, Japan.; Laboratory of Bioresources, National Institute for Basic Biology, Okazaki, Aichi, Japan.; Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan., Mochida K; Tropical Biosphere Research Center, University of the Ryukyus, Nishihara, Okinawa, Japan.; Department of Biology, Keio University, Yokohama, Kanagawa, Japan., Fujimoto S; Tropical Biosphere Research Center, University of the Ryukyus, Nishihara, Okinawa, Japan.; Department of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan., Mokodongan DF; Tropical Biosphere Research Center, University of the Ryukyus, Nishihara, Okinawa, Japan.; Museum Zoologicum Bogoriense (MZB), Zoology Division of Research Center for Biology, Indonesian Institute of Science (LIPI), Cibinong, Indonesia., Sumarto BKA; Tropical Biosphere Research Center, University of the Ryukyus, Nishihara, Okinawa, Japan., Masengi KWA; Faculty of Fisheries and Marine Science, Sam Ratulangi University, Manado, Indonesia., Hadiaty RK; Research Center for Biology, Indonesian Institute of Science (LIPI), Cibinong, Indonesia., Nagano AJ; Faculty of Agriculture, Ryukoku University, Ohtsu, Shiga, Japan., Toyoda A; Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Shizuoka, Japan., Naruse K; Laboratory of Bioresources, National Institute for Basic Biology, Okazaki, Aichi, Japan., Yamahira K; Tropical Biosphere Research Center, University of the Ryukyus, Nishihara, Okinawa, Japan., Kitano J; Ecological Genetics Laboratory, Department of Genomics and Evolutionary Biology, National Institute of Genetics, Mishima, Shizuoka, Japan. jkitano@nig.ac.jp.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Mar 01; Vol. 12 (1), pp. 1350. Date of Electronic Publication: 2021 Mar 01.
DOI: 10.1038/s41467-021-21697-0
Abstrakt: Sexual selection drives rapid phenotypic diversification of mating traits. However, we know little about the causative genes underlying divergence in sexually selected traits. Here, we investigate the genetic basis of male mating trait diversification in the medaka fishes (genus Oryzias) from Sulawesi, Indonesia. Using linkage mapping, transcriptome analysis, and genome editing, we identify csf1 as a causative gene for red pectoral fins that are unique to male Oryzias woworae. A cis-regulatory mutation enables androgen-induced expression of csf1 in male fins. csf1-knockout males have reduced red coloration and require longer for mating, suggesting that coloration can contribute to male reproductive success. Contrary to expectations, non-red males are more attractive to a predatory fish than are red males. Our results demonstrate that integrating genomics with genome editing enables us to identify causative genes underlying sexually selected traits and provides a new avenue for testing theories of sexual selection.
Databáze: MEDLINE
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