Host Genome-Wide Association Study of Infant Susceptibility to Shigella -Associated Diarrhea.
Autor: | Duchen D; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Haque R; International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh., Chen L; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Wojcik G; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Korpe P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Nayak U; Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Mentzer AJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Kirkpatrick B; University of Vermont College of Medicine, Vaccine Testing Center, Burlington, Vermont, USA., Petri WA Jr; Department of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA., Duggal P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA pduggal@jhu.edu. |
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Jazyk: | angličtina |
Zdroj: | Infection and immunity [Infect Immun] 2021 May 17; Vol. 89 (6). Date of Electronic Publication: 2021 May 17 (Print Publication: 2021). |
DOI: | 10.1128/IAI.00012-21 |
Abstrakt: | Shigella is a leading cause of moderate-to-severe diarrhea globally and the causative agent of shigellosis and bacillary dysentery. Associated with 80 to 165 million cases of diarrhea and >13% of diarrheal deaths, in many regions, Shigella exposure is ubiquitous while infection is heterogenous. To characterize host-genetic susceptibility to Shigella -associated diarrhea, we performed two independent genome-wide association studies (GWAS) including Bangladeshi infants from the PROVIDE and CBC birth cohorts in Dhaka, Bangladesh. Cases were infants with Shigella -associated diarrhea ( n = 143) and controls were infants with no Shigella -associated diarrhea in the first 13 months of life ( n = 446). Shigella -associated diarrhea was identified via quantitative PCR (qPCR) threshold cycle ( C (Copyright © 2021 Duchen et al.) |
Databáze: | MEDLINE |
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