| Autor: |
Bitombo AN; Faculty of Science, Department of Organic Chemistry, University of YaoundéI 1, Yaoundé, Cameroon.; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan.; Department of Chemie, Universität of Fribourg, Fribourg, Switzerland., Zintchem AAA; Faculty of Science, Department of Organic Chemistry, University of YaoundéI 1, Yaoundé, Cameroon.; Department of Chemistry, Higher Teacher's Training College, University of YaoundéI 1, Yaoundé, Cameroon., Atchadé AT; Faculty of Science, Department of Organic Chemistry, University of YaoundéI 1, Yaoundé, Cameroon., Moni Ndedi EDF; Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon., Khan A; Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan., Ngono Bikobo DS; Faculty of Science, Department of Organic Chemistry, University of YaoundéI 1, Yaoundé, Cameroon.; Department of Chemie, Universität of Fribourg, Fribourg, Switzerland., Pegnyemb DE; Faculty of Science, Department of Organic Chemistry, University of YaoundéI 1, Yaoundé, Cameroon., Bochet CG; Department of Chemie, Universität of Fribourg, Fribourg, Switzerland. |
| Abstrakt: |
Twenty indole alkaloids, among which two undescribed ones named rauvolfianoids A ( 1 ) and B ( 2 ), were isolated from the stem barks of Rauvolfia caffra Sond along with eight other compounds from other biosynthetic pathways. The structures were elucidated by analysis of spectroscopic data, including 1 D and 2 D NMR; absolute configurations of 1 and 2 were determined by CD exciton chirality method. Compounds 1 and 2 were evaluated for antimicrobial and anticancer activities against three bacterial strains ( Escherichia coli , Shigella sp and Salmonella sp ) and CRC-related opportunistic pathogens. 1 showed moderate antibacterial activity against Salmonella sp with the MIC value of 25 μg/ml, while 2 exhibited weak selective activity against all tested pathogens. In addition, these alkaloids were characterized as weak apoptosis inducers in HCT116 human colon carcinoma cell line. |
