Anti-protozoal activity of Thymol and a Thymol ester against Cryptosporidium parvum in cell culture.
Autor: | Dominguez-Uscanga A; Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Aycart DF; Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Facultad de Ciencias de la Vida, Escuela Superior Politécnica del Litoral, Guayaquil, Ecuador., Li K; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61801, USA., Witola WH; Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 61801, USA., Andrade Laborde JE; Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, 32611, USA. Electronic address: jandrade2@ufl.edu. |
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Jazyk: | angličtina |
Zdroj: | International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2021 Apr; Vol. 15, pp. 126-133. Date of Electronic Publication: 2021 Feb 18. |
DOI: | 10.1016/j.ijpddr.2021.02.003 |
Abstrakt: | Cryptosporidium parvum is a protozoan parasite that infects intestinal epithelial cells causing malabsorption and severe diarrhea. The monoterpene thymol has been reported to have antifungal and antibacterial properties but less is known about the antiparasitic effect of this compound. Terpenes are sometimes unsuitable for therapeutic and food applications because of their instability. Esterification of terpenes eliminates this disadvantage. The present study evaluates the effects of thymol (Th) and a thymol ester, thymol octanoate (TO), against C. parvum infectivity in vitro. The cytotoxicity IC (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
Databáze: | MEDLINE |
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