Detection of antibiotics in the urine of children and pregnant women in Jiangsu, China.

Autor: Zhou YJ; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China., Zhu F; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China., Zheng DY; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China., Gao MM; Yancheng City Center for Disease Control and Prevention, Yancheng, People's Republic of China., Guo BF; Nanjing City Center for Disease Control and Prevention, Nanjing, People's Republic of China., Zhang N; Suzhou City Center for Disease Control and Prevention, Suzhou, People's Republic of China., Meng Y; Wuxi City Center for Disease Control and Prevention, Wuxi, People's Republic of China., Wu GL; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China., Zhou YL; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China. Electronic address: 158582009@qq.com., Huo X; Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China. Electronic address: huox@foxmail.com.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2021 May; Vol. 196, pp. 110945. Date of Electronic Publication: 2021 Feb 26.
DOI: 10.1016/j.envres.2021.110945
Abstrakt: Exposure to low concentrations of antibiotics links to multiple health hazards, such as drug resistance of bacteria, and childhood obesity. In this study, seven antibiotics were measured in the urine of 107 children and 126 pregnant women in Jiangsu Province by ultra-performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). The overall urinary antibiotics detection rate was 38.6%. Most (98.3%) of the participants' antibiotics concentrations were no more than 10 ng/mL. Children had a significantly higher detection rate than pregnant women (47.7% vs. 31.0%, P = 0.009), as well as the concentration (95th percentile: 6.49 vs. 4.08 ng/mL, P = 0.002). The detection rates of individual antibiotics ranged from 0.4% to 15.0%, and the concentrations ranged from lower than the limit of detection (LOD) through up to 31.96 ng/mL individually. Two or more antibiotics were detected in 11.2% of the urines. Tetracyclines were more frequently detected than phenicols (30.9% vs.12.4%). Oxytetracycline was the most frequently detected (15.0%). Multivariate logistic regression showed that consuming puffed food every day was associated with a significantly increased likelihood of detection, and higher concentration of overall antibiotics, and of doxycycline. Children were more likely to be detected of doxycycline and florfenicol, and to have elevated concentration of doxycycline, compared with pregnant women. This study highlights the relatively heavier antibiotics exposure in children, and a possible impact of puffed food on it, which needs to be warranted in future studies.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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