Comparison of single-channel EEG, actigraphy, and sleep diary in cognitively normal and mildly impaired older adults.

Autor:	Chou CA; Department of Neurology, Washington University School of Medicine, St Louis, MO., Toedebusch CD; Department of Neurology, Washington University School of Medicine, St Louis, MO., Redrick T; Department of Neurology, Washington University School of Medicine, St Louis, MO., Freund D; Department of Neurology, Washington University School of Medicine, St Louis, MO., McLeland JS; Department of Neurology, Washington University School of Medicine, St Louis, MO., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, MO.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO., Holtzman DM; Department of Neurology, Washington University School of Medicine, St Louis, MO.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO.; Knight Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO., Lucey BP; Department of Neurology, Washington University School of Medicine, St Louis, MO.; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO.
Jazyk:	angličtina
Zdroj:	Sleep advances : a journal of the Sleep Research Society [Sleep Adv] 2020 Oct 24; Vol. 1 (1), pp. zpaa006. Date of Electronic Publication: 2020 Oct 24 (Print Publication: 2020).
DOI:	10.1093/sleepadvances/zpaa006
Abstrakt:	Study Objectives: Multiple methods for monitoring sleep-wake activity have identified sleep disturbances as risk factors for Alzheimer disease (AD). In order to identify the level of agreement between different methods, we compared sleep parameters derived from single-channel EEG (scEEG), actigraphy, and sleep diaries in cognitively normal and mildly impaired older adults. Methods: Two hundred ninety-three participants were monitored at home for up to six nights with scEEG, actigraphy, and sleep diaries. Total sleep time (TST), sleep efficiency (SE), sleep onset latency (SOL), and wake after sleep onset (WASO) were calculated using each of these methods. In 109 of the 293 participants, the ratio of cerebrospinal fluid concentrations of phosphorylated tau (p-tau) and amyloid-β-42 (Aβ42) was used as a biomarker for AD pathology. Results: Agreement was highest for TST across instruments, especially in cognitively normal older adults. Overall, scEEG and actigraphy appeared to have greater agreement for multiple sleep parameters than for scEEG and diary or actigraphy and diary. Levels of agreement between scEEG and actigraphy overall decreased in mildly impaired participants and those with biomarker evidence of AD pathology, especially for measurements of TST. Conclusions: Caution should be exercised when comparing scEEG and actigraphy in individuals with mild cognitive impairment or with AD pathology. Sleep diaries may capture different aspects of sleep compared to scEEG and actigraphy. Additional studies comparing different methods of measuring sleep-wake activity in older adults are necessary to allow for comparison between studies using different methods. (© The Author(s) 2020. Published by Oxford University Press on behalf of Sleep Research Society.)
Databáze:	MEDLINE
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