Exercise interventions do not impact brain volume change in older adults: a systematic review and meta-analysis.

Autor: Gogniat MA; University of Georgia, Department of Psychology, Athens, Georgia. Electronic address: mag53440@uga.edu., Robinson TL; University of Georgia, Department of Psychology, Athens, Georgia., Miller LS; University of Georgia, Department of Psychology, Athens, Georgia.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2021 May; Vol. 101, pp. 230-246. Date of Electronic Publication: 2021 Feb 03.
DOI: 10.1016/j.neurobiolaging.2021.01.025
Abstrakt: Exercise interventions have been shown to positively impact cognitive function in older adults, but the mechanisms underlying the neuroprotective effects of exercise on the brain are not well understood. Here, we aimed to synthesize and quantitatively analyze the current literature on exercise interventions and brain volume change in older adults and to examine the impact of key demographic and intervention features as well as study quality. This study was pre-registered with PROSPERO (CRD42018091866). EBSCOhost, Cochrane Library, Embase, and reference lists were searched to identify randomized-controlled trials (RCTs) of exercise interventions for healthy older adults and older adults (60+) with mild cognitive impairment (MCI). A total of 69 effects from 14 studies were pooled and expressed as Hedge's g using a random-effects model. Results indicated that there was no significant difference in brain volume outcomes for older adults that completed an exercise intervention compared to older adults in control groups (g = 0.012, p = 0.728, 95% CI = -0.055, .078). These results were confirmed using multilevel analysis to account for nesting of effects within studies (g = 0.009, p = 0.826, 95% CI = -0.072, 0.090) and using conservative post-hoc models to address possible non-independence of multiple outcome domains and sample nonindependence. No significant heterogeneity was detected, limiting moderator analyses. The implications for future research are discussed.
Competing Interests: Conflicts of Interest The authors have no funding sources or conflicts of interest to disclose.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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