Cognitive and behavioral profiles of pediatric surgical candidates with frontal and temporal lobe epilepsy.

Autor: Esteso Orduña B; Clinical Neuropsychology Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. Electronic address: borja.esteso@salud.madrid.org., Fournier Del Castillo MC; Clinical Neuropsychology Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Cámara Barrio S; Clinical Neuropsychology Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., García Fernández M; Epilepsy Monitoring Unit, Clinical Neurophysiology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Andrés Esteban EM; Biomedical Research Foundation, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Álvarez-Linera Prado J; Neuroradiology Department, Hospital Ruber Internacional, Madrid, Spain., Budke M; Neurosurgery Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Maldonado Belmonte MJ; Brain Damage Rehabilitation Unit, Hospital Central de la Cruz Roja San José y Santa Adela, Madrid, Spain., González Marqués J; Cognitive Processes Department, Faculty of Psychology, Universidad Complutense de Madrid, Madrid, Spain., Pérez Jiménez MÁ; Epilepsy Monitoring Unit, Clinical Neurophysiology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2021 Apr; Vol. 117, pp. 107808. Date of Electronic Publication: 2021 Feb 25.
DOI: 10.1016/j.yebeh.2021.107808
Abstrakt: Background: We aimed to prospectively analyze memory and executive and social cognitive functioning in patients with drug-resistant frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE) with focal lesions and isolate the impact of intellectual ability on specific deficits.
Methods: A neuropsychological evaluation was performed in 23 children with FLE, 22 children with TLE, and 36 healthy pediatric controls (HCs). Patients in the epilepsy groups had a range of lesions, including low-grade epilepsy-associated tumors (LEAT), focal cortical dysplasia (FCD) type II, and mesial temporal sclerosis (MS).
Results: There were no significant differences between children with FLE and TLE regarding memory, executive, or social cognitive functioning. General Ability Index (GAI) was a predictor of memory, executive function, and social cognition scores and was influenced by age at onset, duration of epilepsy, and number of antiepileptic drugs (AEDs) prescribed at the time of assessment. Working Memory Index scores of patients with TLE, which measure verbal mnesic processing, were significantly lower than those of HCs and patients with TLE. The greatest differences in both clinical groups compared to HCs were recorded in cognitive executive functions, and patients with FLE had lower scores in this domain. Regarding behavioral executive functions, patients with TLE presented impaired emotional control and impulse inhibition and patients with FLE exhibited decreased flexibility.
Conclusion: Consistent with previous research, our findings provide further detailed evidence of small differences in cognitive performance among children with FLE and TLE. These differences emerge on analysis of the factors with which deficits are associated.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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