Towards a unification of treatments and interventions for tinnitus patients: The EU research and innovation action UNITI.

Autor:	Schlee W; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany. Electronic address: winfried.schlee@ieee.org., Schoisswohl S; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Staudinger S; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Schiller A; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Lehner A; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Langguth B; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Schecklmann M; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Simoes J; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Neff P; Department of Psychiatry and Psychotherapy, Bezirksklinikum, University of Regensburg, Regensburg, Germany., Marcrum SC; Ear, Nose, Throat Department, University Hospital Regensburg, Regensburg, DE, Germany., Spiliopoulou M; Department of Informatics, Knowledge Management and Discovery Lab, Otto-von-Guericke-University Magdeburg, Magdeburg, DE, Germany., Niemann U; Department of Informatics, Knowledge Management and Discovery Lab, Otto-von-Guericke-University Magdeburg, Magdeburg, DE, Germany., Schleicher M; Department of Informatics, Knowledge Management and Discovery Lab, Otto-von-Guericke-University Magdeburg, Magdeburg, DE, Germany., Unnikrishnan V; Department of Informatics, Knowledge Management and Discovery Lab, Otto-von-Guericke-University Magdeburg, Magdeburg, DE, Germany., Puga C; Department of Informatics, Knowledge Management and Discovery Lab, Otto-von-Guericke-University Magdeburg, Magdeburg, DE, Germany., Mulansky L; University Hospital Wuerzburg, Institute for Clinical Epidemiology and Biometry (IKE-B), Wuerzburg, DE, Germany., Pryss R; University Hospital Wuerzburg, Institute for Clinical Epidemiology and Biometry (IKE-B), Wuerzburg, DE, Germany., Vogel C; University Hospital Wuerzburg, Institute for Clinical Epidemiology and Biometry (IKE-B), Wuerzburg, DE, Germany., Allgaier J; University Hospital Wuerzburg, Institute for Clinical Epidemiology and Biometry (IKE-B), Wuerzburg, DE, Germany., Giannopoulou E; ZEINCRO Egeszegugyi Szolgaltato Korlatolt Felelossegu Tarsasag, Budakalasz, HU, Hungary., Birki K; ZEINCRO Egeszegugyi Szolgaltato Korlatolt Felelossegu Tarsasag, Budakalasz, HU, Hungary., Liakou K; ZEINCRO Egeszegugyi Szolgaltato Korlatolt Felelossegu Tarsasag, Budakalasz, HU, Hungary., Cima R; Department of Health Psychology, Katholieke Universiteit Leuven, Leuven, Belgium., Vlaeyen JWS; Department of Health Psychology, Katholieke Universiteit Leuven, Leuven, Belgium., Verhaert N; Department of Health Psychology, Katholieke Universiteit Leuven, Leuven, Belgium., Ranson S; Adelante Tinnitus Expertise Centre, Maastricht, NL, The Netherlands., Mazurek B; Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Brueggemann P; Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Boecking B; Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Amarjargal N; Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Specht S; Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Stege A; Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany; Charité University Hospital Berlin, Centrale Biobank Charité (ZeBanC), Berlin, DE, Germany., Hummel M; Tinnitus Center, Charité-Universitätsmedizin Berlin, Berlin, Germany; Charité University Hospital Berlin, Centrale Biobank Charité (ZeBanC), Berlin, DE, Germany., Rose M; Charité University Hospital Berlin, Dept of Psychosomatic and Psychotherapy, Berlin, DE, Germany., Oppel K; Terzo-Institut für angewandte Gehörforschung, Berlin, DE, Germany., Dettling-Papargyris J; Terzo-Institut für angewandte Gehörforschung, Berlin, DE, Germany., Lopez-Escamez JA; Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, ES, Spain; Department of Otolaryngology, Instituto de Investigación Biosanitaria Ibs. Granada, Hospital Universitario Virgen de las Nieves, Granada, ES, Spain; Department of Surgery, Division of Otolaryngology, Universidad de Granada, Granada, ES, Spain., Amanat S; Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, ES, Spain., Gallego-Martinez A; Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, ES, Spain., Escalera-Balsera A; Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, ES, Spain., Espinosa-Sanchez JM; Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO. Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, ES, Spain; Department of Otolaryngology, Instituto de Investigación Biosanitaria Ibs. Granada, Hospital Universitario Virgen de las Nieves, Granada, ES, Spain., Garcia-Valdecasas J; Department of Otolaryngology, Instituto de Investigación Biosanitaria Ibs. Granada, Hospital Universitario Virgen de las Nieves, Granada, ES, Spain., Mata-Ferron M; Department of Otolaryngology, Instituto de Investigación Biosanitaria Ibs. Granada, Hospital Universitario Virgen de las Nieves, Granada, ES, Spain., Martin-Lagos J; Department of Otolaryngology, Instituto de Investigacion Biosanitaria ibs. Granada, Hospital Universitario Clinico San Cecilio, Granada, ES, Spain., Martinez-Martinez M; Department of Otolaryngology, Instituto de Investigacion Biosanitaria ibs. Granada, Hospital Universitario Clinico San Cecilio, Granada, ES, Spain., Martinez-Martinez MJ; Department of Otolaryngology, Instituto de Investigación Biosanitaria Ibs. Granada, Hospital Universitario Virgen de las Nieves, Granada, ES, Spain., Müller-Locatelli N; Department of Otolaryngology, Instituto de Investigacion Biosanitaria ibs. Granada, Hospital Universitario Clinico San Cecilio, Granada, ES, Spain., Perez-Carpena P; Department of Otolaryngology, Instituto de Investigacion Biosanitaria ibs. Granada, Hospital Universitario Clinico San Cecilio, Granada, ES, Spain., Alcazar-Beltran J; Department of Mental Health, Hospital Universitario Virgen de las Nieves, Granada, ES, Spain., Hidalgo-Lopez L; Department of Mental Health, Hospital Universitario Virgen de las Nieves, Granada, ES, Spain., Vellidou E; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Sarafidis M; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Katrakazas P; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Kostaridou V; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Koutsouris D; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Manta R; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Paraskevopoulos E; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Haritou M; Institute of Communication and Computer Systems (ICCS), Athens, GR, Greece., Elgoyhen AB; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, 'Dr. Héctor N. Torres' (INGEBI), Buenos Aires, AR, Argentina., Goedhart H; TinnitusHub, Hemsworth, United Kingdom., Koller M; Center for Clinical Studies, University Hospital Regensburg, Regensburg, DE, Germany., Shekhawat GS; College of Nursing and Health Sciences, Flinders University, Bedford Park, SA, Australia; Ear Institute, University College London, London, United Kingdom; Tinnitus Research Initiative, Regensburg, Germany., Crump H; Patient Organisation 'Hast Du Töne' Bergisch-Gladbach, Bergisch-Gladbach, DE, Germany., Hannemann R; Sivantos GmbH, Erlangen, Germany., Holfelder M; LA2 GmbH, Erlangen, DE, Germany., Oberholzer T; WIA Ventures GmbH, Aarau, CH, Switzerland., Vontas A; VILABS LTD, Limassol, CY, Cyprus., Trochidis I; VILABS LTD, Limassol, CY, Cyprus., Moumtzi V; VILABS LTD, Limassol, CY, Cyprus., Cederroth CR; Karolinska Institutet, Department of Physiology and Pharmacology, Stockholm, SE, Sweden., Koloutsou K; SPHYNX Technology Solutions AG, Zug, CH, Switzerland., Spanoudakis G; SPHYNX Technology Solutions AG, Zug, CH, Switzerland., Basdekis I; SPHYNX Technology Solutions AG, Zug, CH, Switzerland., Gallus S; Laboratory of Lifestyle Epidemiology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Lugo A; Laboratory of Lifestyle Epidemiology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Stival C; Laboratory of Lifestyle Epidemiology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Borroni E; Laboratory of Lifestyle Epidemiology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Markatos N; National and Kapodistrian University of Athens, Hippocrateion Hospital, Department of Otolaryngology, Athens, GR, Greece., Bibas A; National and Kapodistrian University of Athens, Hippocrateion Hospital, Department of Otolaryngology, Athens, GR, Greece., Kikidis D; National and Kapodistrian University of Athens, Hippocrateion Hospital, Department of Otolaryngology, Athens, GR, Greece.
Jazyk:	angličtina
Zdroj:	Progress in brain research [Prog Brain Res] 2021; Vol. 260, pp. 441-451. Date of Electronic Publication: 2021 Feb 04.
DOI:	10.1016/bs.pbr.2020.12.005
Abstrakt:	Tinnitus is the perception of a phantom sound and the patient's reaction to it. Although much progress has been made, tinnitus remains a scientific and clinical enigma of high prevalence and high economic burden, with an estimated prevalence of 10%-20% among the adult population. The EU is funding a new collaborative project entitled "Unification of Treatments and Interventions for Tinnitus Patients" (UNITI, grant no. 848261) under its Horizon 2020 framework. The main goal of the UNITI project is to set the ground for a predictive computational model based on existing and longitudinal data attempting to address the question of which treatment or combination of treatments is optimal for a specific patient group based on certain parameters. Clinical, epidemiological, genetic and audiological data, including signals reflecting ear-brain communication, as well as patients' medical history, will be analyzed making use of existing databases. Predictive factors for different patient groups will be extracted and their prognostic relevance validated through a Randomized Clinical Trial (RCT) in which different patient groups will undergo a combination of tinnitus therapies targeting both auditory and central nervous systems. From a scientific point of view, the UNITI project can be summarized into the following research goals: (1) Analysis of existing data: Results of existing clinical studies will be analyzed to identify subgroups of patients with specific treatment responses and to identify systematic differences between the patient groups at the participating clinical centers. (2) Genetic and blood biomarker analysis: High throughput Whole Exome Sequencing (WES) will be performed in well-characterized chronic tinnitus cases, together with Proximity Extension Assays (PEA) for the identification of blood biomarkers for tinnitus. (3) RCT: A total of 500 patients will be recruited at five clinical centers across Europe comparing single treatments against combinational treatments. The four main treatments are Cognitive Behavioral Therapy (CBT), hearing aids, sound stimulation, and structured counseling. The consortium will also make use of e/m-health applications for the treatment and assessment of tinnitus. (4) Decision Support System: An innovative Decision Support System will be implemented, integrating all available parameters (epidemiological, clinical, audiometry, genetics, socioeconomic and medical history) to suggest specific examinations and the optimal intervention strategy based on the collected data. (5) Financial estimation analysis: A cost-effectiveness analysis for the respective interventions will be calculated to investigate the economic effects of the interventions based on quality-adjusted life years. In this paper, we will present the UNITI project, the scientific questions that it aims to address, the research consortium, and the organizational structure. (© 2021 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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