The impact of physical activity and exercise interventions for physical health in people with cystic fibrosis: protocol for a systematic review.

Autor: Tomlinson OW; Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Heavitree Road, Exeter, EX1 2LU, UK.; Royal Devon and Exeter NHS Foundation Trust Hospital, Barrack Road, Exeter, EX2 5DW, UK., Denford S; Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Heavitree Road, Exeter, EX1 2LU, UK.; Centre for Public Health and Epidemiology, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2PS, UK., Barker AR; Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Heavitree Road, Exeter, EX1 2LU, UK., Schneiderman JE; Division of Respiratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada., Campisi ES; University of Toronto, 27 King's College Circle, Toronto, Ontario, M5S 1A1, Canada., Douglas H; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.; Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK., Rand S; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK., McNarry MA; Applied Sports, Technology, Exercise and Medicine Research Centre, College of Engineering, Bay Campus, Swansea University, Fabian Way, Swansea, SA1 8EN, UK., Mackintosh KA; Applied Sports, Technology, Exercise and Medicine Research Centre, College of Engineering, Bay Campus, Swansea University, Fabian Way, Swansea, SA1 8EN, UK., Williams CA; Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Heavitree Road, Exeter, EX1 2LU, UK. C.A.Williams@exeter.ac.uk.; Royal Devon and Exeter NHS Foundation Trust Hospital, Barrack Road, Exeter, EX2 5DW, UK. C.A.Williams@exeter.ac.uk.
Jazyk: angličtina
Zdroj: Systematic reviews [Syst Rev] 2021 Feb 26; Vol. 10 (1), pp. 64. Date of Electronic Publication: 2021 Feb 26.
DOI: 10.1186/s13643-021-01614-8
Abstrakt: Background: Cystic fibrosis (CF) is a genetically inherited, life-limiting condition, affecting ~90,000 people globally. Physical activity (PA) and exercise form an integral component of CF management, and have been highlighted by the CF community as an area of interest for future research. Previous reviews have solely focused on PA or structured exercise regimens independent of one another, and thus a comprehensive assessment of the physical health benefits of all PA, including exercise, interventions, is subsequently warranted. Therefore, the purpose of this review is to evaluate the effects of both PA and exercise upon outcomes of physical health and healthcare utilisation in people with CF.
Methods: A systematic review has been registered and reported in line with Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P guidelines. This will include randomised control trials on the effects of PA and exercise, relative to usual treatment, upon people with CF. Primary outcomes will include variables associated with fitness, PA, lung health, inflammation, body composition, glycaemic control and patient-reported outcomes. Secondary outcomes will include adverse events and healthcare utilisation. Searches will be undertaken in Ovid MEDLINE, OVID EMBASE, PsychINFO, ERIC, SPORTDiscus, ASSIA, CCTR, CINHAL and Web of Science databases, and will be searched from date of inception onwards. Two reviewers will independently screen citations and abstracts, and full-texts, for inclusion and data extraction, respectively. Methodological quality will be assessed using the Cochrane Risk of Bias-2 tool. If feasible, random-effects meta-analyses will be conducted where appropriate. Additional analyses will explore potential sources of heterogeneity, such as age, sex, and disease severity.
Discussion: This systematic review will build on previous research, by comprehensively assessing the impact of both PA and exercise upon physical health and healthcare utilisation in people with CF. Results of this review will be utilised to inform discussions that will ultimately result in a consensus document on the impact of physical activity and exercise for people with CF.
Systematic Review Registration: PROSPERO CRD42020184411.
Databáze: MEDLINE
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