Pulmonary Abnormalities in Liver Disease: Relevance to Transplantation and Outcome.

Autor: Raevens S; Department of Gastroenterology and Hepatology, Ghent University-Ghent University Hospital, Ghent, Belgium., Boret M; Department of Gastroenterology and Hepatology, Ghent University-Ghent University Hospital, Ghent, Belgium., De Pauw M; Department of Cardiology, Ghent University-Ghent University Hospital, Ghent, Belgium., Fallon MB; Department of Internal Medicine, University of Arizona College of Medicine, Phoenix, AZ., Van Vlierberghe H; Department of Gastroenterology and Hepatology, Ghent University-Ghent University Hospital, Ghent, Belgium.
Jazyk: angličtina
Zdroj: Hepatology (Baltimore, Md.) [Hepatology] 2021 Sep; Vol. 74 (3), pp. 1674-1686. Date of Electronic Publication: 2021 May 24.
DOI: 10.1002/hep.31770
Abstrakt: Pulmonary disease in liver cirrhosis and portal hypertension (PH) constitutes a challenging clinical scenario and may have important implications with regard to prognosis, liver transplantation (LT) candidacy, and post-LT outcome. Pre-LT evaluation should include adequate screening for pulmonary diseases that may occur concomitantly with liver disease as well as for those that may arise as a complication of end-stage liver disease and PH, given that either may jeopardize safe LT and successful outcome. It is key to discriminate those patients who would benefit from LT, especially pulmonary disorders that have been reported to resolve post-LT and are considered "pulmonary indications" for transplant, from those who are at increased mortality risk and in whom LT is contraindicated. In conclusion, in this article, we review the impact of several pulmonary disorders, including cystic fibrosis, alpha 1-antitrypsin deficiency, hereditary hemorrhagic telangiectasia, sarcoidosis, coronavirus disease 2019, asthma, chronic obstructive pulmonary disease, pulmonary nodules, interstitial lung disease, hepatic hydrothorax, hepatopulmonary syndrome, and portopulmonary hypertension, on post-LT survival, as well as the reciprocal impact of LT on the evolution of lung function.
(© 2021 by the American Association for the Study of Liver Diseases.)
Databáze: MEDLINE
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