| Autor: |
Gaddale Devanna KK; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK. Richard.Hartley@glasgow.ac.uk., Gawel JM, Prime TA, Cvetko F, Benincá C, Caldwell ST, Negoda A, Harrison A, James AM, Pavlov EV, Murphy MP, Hartley RC |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Mar 28; Vol. 57 (25), pp. 3147-3150. Date of Electronic Publication: 2021 Feb 26. |
| DOI: |
10.1039/d0cc07924c |
| Abstrakt: |
Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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